Evidence map›Paper›PMID 26442957›Full record

SynthesisJournal of psychopharmacology (Oxford, England)2015

Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin.

Frederick S Barrett, Matthew W Johnson, Roland R Griffiths

5 registry-linked trialsOpen access · greenAbstract readMeta-AnalysisMulticenter StudyValidation Study
In one paragraph

Synthesis in Journal of psychopharmacology (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 272 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
272citing papers in PubMed, 4 pooled it
20.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05894902 phase1unknown statusnot on this mapstarted 2023, after this paper: background citation

Open-Label Dose-Ranging Study of Oral SM-001 in Healthy Adults

TypeinterventionalSponsorAdvanced Integrative Medical Science InstituteRan2023 to 2024Enrolled12ConditionsMajor Depression, Post Traumatic Stress DisorderArmsSM-001
NCT06303739 phase3active not recruitingnot on this mapstarted 2024, after this paper: background citation

Induction Protocol for Psilocybin-Assisted Therapy in Treatment-Resistant Depression (TRD): A Pilot Study

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2024 to 2027Enrolled20ConditionsRefractory Depression, Treatment Resistant DepressionArmspsilocybin
NCT06355414 phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Psilocybin and Affective Function in Chronic Lower Back Pain Depression

TypeinterventionalSponsorJohns Hopkins UniversityRan2024 to 2026Enrolled40ConditionsChronic Low-back Pain, DepressionArmsPsilocybin, Methylphenidate
NCT06772753 phase1recruitingnot on this mapstarted 2025, after this paper: background citation

Investigation of Psychedelic Effects in Psychoactive Substances

TypeinterventionalSponsorJohns Hopkins UniversityRan2025 to 2027Enrolled50ConditionsPsychedelic Effects in Healthy VolunteersArmsPlacebo, Psilocybin, Ketamine, Dextromethorphan (DXM), Dimethyltryptamine (DMT)
NCT07584070 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Mystical Experiences Without Psychedelics: The Nature of Peak Spiritual Experiences and How Integration Leads to Human Flourishing

TypeinterventionalSponsorBaylor UniversityRan2026 to 2027Enrolled120ConditionsHealthy Adult ParticipantsArmsGuided Invocation for Mystical Experience
3 · Its place in the literature

Who cites it

272 citing papers in PubMed, 4 syntheses or guidelines pooled it, 612 citations in OpenAlex.

  1. Pooled it
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  5. Acute and post-acute neurobehavioral responses to lysergic acid diethylamide in healthy subjects: a randomized controlled study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  12. A novel psychedelic 5-HTJournal of psychopharmacology (Oxford, England) · 2026
    Trial
  13. Acute effects of MDMA, MDA, lysine-MDMA, and lysine-MDA in a randomized, double-blind, placebo-controlled, crossover trial in healthy participants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  18. Rapid and sustained antidepressant effects of vaporized N,N-dimethyltryptamine: a phase 2a clinical trial in treatment-resistant depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
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  19. Trial
  20. Acute effects of R-MDMA, S-MDMA, and racemic MDMA in a randomized double-blind cross-over trial in healthy participants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Trial

212 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Frederick S BarrettDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA fbarret2@jhu.edu.
Matthew W JohnsonDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Roland R GriffithsDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

HUMAN BEHAVIORAL PHARMACOLOGY OF SUBSTANCE ABUSET32DA007209 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Eric C. Strain, Elise M Weerts · 1985 to 2026
$12.9M
Human Clinical Pharmacology of Emerging Drugs of Abuse (Club Drugs)R01DA003889 · NIDA · JOHNS HOPKINS UNIVERSITY · PI GRIFFITHS, ROLAND R · 1985 to 2017
$7.6M
NIDA NIH HHS R01 DA003889NIDA NIH HHS R01 DA03889NIDA NIH HHS T32 DA007209
6 · The paper itself

Abstract

The 30-item revised Mystical Experience Questionnaire (MEQ30) was previously developed within an online survey of mystical-type experiences occasioned by psilocybin-containing mushrooms. The rated experiences occurred on average eight years before completion of the questionnaire. The current paper validates the MEQ30 using data from experimental studies with controlled doses of psilocybin. Data were pooled and analyzed from five laboratory experiments in which participants (n=184) received a moderate to high oral dose of psilocybin (at least 20 mg/70 kg). Results of confirmatory factor analysis demonstrate the reliability and internal validity of the MEQ30. Structural equation models demonstrate the external and convergent validity of the MEQ30 by showing that latent variable scores on the MEQ30 positively predict persisting change in attitudes, behavior, and well-being attributed to experiences with psilocybin while controlling for the contribution of the participant-rated intensity of drug effects. These findings support the use of the MEQ30 as an efficient measure of individual mystical experiences. A method to score a "complete mystical experience" that was used in previous versions of the mystical experience questionnaire is validated in the MEQ30, and a stand-alone version of the MEQ30 is provided for use in future research.

Indexed as

Administration, OralHallucinogensHumansMysticismPsilocybinSurveys and QuestionnairesHallucinogensPsilocybinentheogenfactor analysishallucinogensmystical experiencePsilocybinpsychedelicpsychometricsspiritualstructural equation modeling

Identifiers

PMID26442957
PMCPMC5203697
OpenAlexW2340085151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.