Evidence map›Paper›PMID 26442933›Full record

ArticleEcoSal Plus2014

The EcoCyc Database.

Peter D Karp, Daniel Weaver, Suzanne Paley, Carol Fulcher, Aya Kubo, Anamika Kothari, Markus Krummenacker, Pallavi Subhraveti, Deepika Weerasinghe, Socorro Gama-Castro and 12 more

Abstract read
In one paragraph

Article in EcoSal Plus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Insights into antibiotic resistance promoted by quinolone exposure.Antimicrobial agents and chemotherapy · 2025
    Article
  3. Review
  4. Article
  5. Microorganisms · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Valine-Induced Isoleucine Starvation inFrontiers in genetics · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Repurposing type III polyketide synthase as a malonyl-CoA biosensor for metabolic engineering in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Peter D KarpBioinformatics Research Group, SRI International, Menlo Park, CA 94025.
Daniel WeaverBioinformatics Research Group, SRI International, Menlo Park, CA 94025.
Suzanne PaleyBioinformatics Research Group, SRI International, Menlo Park, CA 94025.
Carol FulcherBioinformatics Research Group, SRI International, Menlo Park, CA 94025.
Aya KuboBioinformatics Research Group, SRI International, Menlo Park, CA 94025.
Anamika KothariBioinformatics Research Group, SRI International, Menlo Park, CA 94025.
Markus KrummenackerBioinformatics Research Group, SRI International, Menlo Park, CA 94025.
Pallavi SubhravetiBioinformatics Research Group, SRI International, Menlo Park, CA 94025.
Deepika WeerasingheBioinformatics Research Group, SRI International, Menlo Park, CA 94025.
Socorro Gama-CastroPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, México.
Araceli M HuertaPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, México.
Luis Muñiz-RascadoPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, México.
César Bonavides-MartinezPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, México.
Verena WeissPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, México.
Martin Peralta-GilPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, México.
Alberto Santos-ZavaletaPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, México.
Imke SchröderDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Amanda MackieDepartment of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia.
Robert GunsalusDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Julio Collado-VidesPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, México.
Ingrid M KeselerBioinformatics Research Group, SRI International, Menlo Park, CA 94025.
Ian PaulsenDepartment of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia.

Funding

The EcoCyc Model Organism Database for Escherichia coli [SRI Proposal ECU 14-631]U24GM077678 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2006 to 2018
$12.3M
The EcoCyc Model Organism Database for Escherichia coliR01GM077678 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2019 to 2022
$4.6M
Gene Regulation: E.coli Database Integrated ModelingR01GM071962 · NIGMS · CENTER FOR GENOMIC SCIENCES · PI COLLADO-VIDES, JULIO · 2004 to 2011
$2.4M
NIGMS NIH HHS R01 GM071962NIGMS NIH HHS R01 GM077678NIGMS NIH HHS U24 GM077678
6 · The paper itself

Abstract

EcoCyc is a bioinformatics database available at EcoCyc.org that describes the genome and the biochemical machinery of Escherichia coli K-12 MG1655. The long-term goal of the project is to describe the complete molecular catalog of the E. coli cell, as well as the functions of each of its molecular parts, to facilitate a system-level understanding of E. coli. EcoCyc is an electronic reference source for E. coli biologists and for biologists who work with related microorganisms. The database includes information pages on each E. coli gene, metabolite, reaction, operon, and metabolic pathway. The database also includes information on E. coli gene essentiality and on nutrient conditions that do or do not support the growth of E. coli. The website and downloadable software contain tools for analysis of high-throughput data sets. In addition, a steady-state metabolic flux model is generated from each new version of EcoCyc. The model can predict metabolic flux rates, nutrient uptake rates, and growth rates for different gene knockouts and nutrient conditions. This review provides a detailed description of the data content of EcoCyc and of the procedures by which this content is generated.

Identifiers

PMID26442933
PMCPMC4243172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.