Evidence map›Paper›PMID 26442925›Full record

ArticleCell stress & chaperones2016

CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma.

Daniela Cabibi, Everly Conway de Macario, Sabrina Ingrao, Rossana Porcasi, Francesco Zucco, Alberto J L Macario, Francesco Cappello, Francesca Rappa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stress & chaperones, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Mitochondrial function - gatekeeper of intestinal epithelial cell homeostasis.Nature reviews. Gastroenterology & hepatology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniela CabibiPathology Institute, Department "G. D'Alessandro", University of Palermo, Palermo, Italy.
Everly Conway de MacarioDepartment of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore and IMET, Columbus Center, Baltimore, MD, USA.
Sabrina IngraoPathology Institute, Department "G. D'Alessandro", University of Palermo, Palermo, Italy.
Rossana PorcasiPathology Institute, Department "G. D'Alessandro", University of Palermo, Palermo, Italy.
Francesco ZuccoPathology Institute, Department "G. D'Alessandro", University of Palermo, Palermo, Italy.
Alberto J L MacarioDepartment of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore and IMET, Columbus Center, Baltimore, MD, USA.
Francesco CappelloEuro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy.
Francesca RappaEuro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy. francyrappa@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD1a is involved in presentation to the immune system of lipid antigen derived from tumor cells with subsequent T cell activation. Hsp60 is a molecular chaperone implicated in carcinogenesis by, for instance, modulating the immune reaction against the tumor. We have previously postulated a synergism between CD1a and Hsp60 as a key factor in the activation of an effective antitumor immune response in squamous epithelia. Keratoacantomas (KAs) are benign tumors that however can transform into squamous cell carcinomas (SCCs), but the reasons for this malignization are unknown. In a previous study, we found that CD1a-positive cells are significantly more numerous in KA than in SCC. In this study, we analyzed a series of KAs and SCCs by immunohistochemistry for CD1a and Hsp60. Our results show that the levels of both are significantly lower in KA than in SCC and support the hypothesis that KA may evolve towards SCC if there is a failure of the local modulation of the antitumor immune response. The data also show that immunohistochemistry for CD1a and Hsp60 can be of help in differential diagnosis between KAs and well-differentiated forms of SCC.

Indexed as

AdultAgedAged, 80 and overAntigens, CD1Biomarkers, TumorCarcinoma, Squamous CellChaperonin 60Diagnosis, DifferentialHumansImmunohistochemistryKeratoacanthomaMiddle AgedMitochondrial ProteinsRetrospective StudiesYoung AdultAntigens, CD1Biomarkers, TumorCD1a antigenChaperonin 60HSPD1 protein, humanMitochondrial ProteinsCD1aDifferential diagnosisHsp60ImmunohistochemistryKeratoacantomaPrognostic evaluationSquamous cell carcinomaTreatment

Identifiers

PMID26442925
PMCPMC4679739

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.