Evidence map›Paper›PMID 26442861›Full record

ArticleDrugs & aging2015

Prevalence of Potential and Clinically Relevant Statin-Drug Interactions in Frail and Robust Older Inpatients.

Michele Thai, Sarah Hilmer, Sallie-Anne Pearson, Emily Reeve, Danijela Gnjidic

Abstract read
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In one paragraph

Article in Drugs & aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Review
  6. An International Perspective on Chronic Multimorbidity: Approaching the Elephant in the Room.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018
    Article
  7. Article
  8. Prescribing for frail older people.Australian prescriber · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michele ThaiFaculty of Pharmacy, The University of Sydney, Sydney, NSW, 2006, Australia. mtha3748@uni.sydney.edu.au.
Sarah HilmerSydney Medical School, The University of Sydney, Sydney, NSW, Australia.
Sallie-Anne PearsonFaculty of Pharmacy, The University of Sydney, Sydney, NSW, 2006, Australia.
Emily ReeveSydney Medical School, The University of Sydney, Sydney, NSW, Australia.
Danijela GnjidicFaculty of Pharmacy, The University of Sydney, Sydney, NSW, 2006, Australia. danijela.gnjidic@sydney.edu.au.
University of Sydney · AURoyal North Shore Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA significant proportion of older people are prescribed statins and are also exposed to polypharmacy, placing them at increased risk of statin-drug interactions.

objectiveTo describe the prevalence rates of potential and clinically relevant statin-drug interactions in older inpatients according to frailty status.

methodsA cross-sectional study of patients aged ≥65 years who were prescribed a statin and were admitted to a teaching hospital between 30 July and 10 October 2014 in Sydney, Australia, was conducted. Data on socio-demographics, comorbidities and medications were collected using a standardized questionnaire. Potential statin-drug interactions were defined if listed in the Australian Medicines Handbook and three international drug information sources: the British National Formulary, Drug Interaction Facts and Drug-Reax(®). Clinically relevant statin-drug interactions were defined as interactions with the highest severity rating in at least two of the three international drug information sources. Frailty was assessed using the Reported Edmonton Frail Scale.

resultsA total of 180 participants were recruited (median age 78 years, interquartile range 14), 35.0% frail and 65.0% robust. Potential statin-drug interactions were identified in 10% of participants, 12.7% of frail participants and 8.5% of robust participants. Clinically relevant statin-drug interactions were identified in 7.8% of participants, 9.5% of frail participants and 6.8% of robust participants. Depending on the drug information source used, the prevalence rates of potential and clinically relevant statin-drug interactions ranged between 14.4 and 35.6% and between 14.4 and 20.6%, respectively.

conclusionIn our study of frail and robust older inpatients taking statins, the overall prevalence of potential statin-drug interactions was low and varied significantly according to the drug information source used.

Indexed as

Drug-Related Side Effects and Adverse ReactionsFrail ElderlyAgedAged, 80 and overAustraliaComorbidityCross-Sectional StudiesDrug InteractionsFemaleHospitalizationHospitals, TeachingHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInpatientsMaleMiddle AgedHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID26442861
OpenAlexW1856844341

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.