ReviewDrugs & aging2015
Tolerability of Antihypertensive Medications in Older Adults.
Review in Drugs & aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Correlation between pharmacologic blood pressure-lowering intensity and improvement in cardiac function in patients with acutely decompensated heart failure.BMC cardiovascular disorders · 2026Article
- Development of nifedipine isosteres: an integrated approach to the design, synthesis, and biological assessment of calcium channel blockers.Frontiers in chemistry · 2025Article
- Excessive Daytime Sleepiness in Hypertensive Patients: The Role of Major Depressive Disorder.Diagnostics (Basel, Switzerland) · 2024Article
- Tolerability of Antihypertensive Medications: The Influence of Age.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Article
- Correlation of polypill and blood pressure level: A systematic review of clinical trials.Journal of education and health promotion · 2023Article
- Research on Beers Criteria and STOPP/START Criteria based on the FDA FAERS database.European journal of clinical pharmacology · 2021Article
- Beneficial Effects of Spirulina Aqueous Extract on Vasodilator Function of Arteries from Hypertensive Rats.International journal of vascular medicine · 2020Article
- Long-term thiazide use and risk of low-energy fractures among persons with Alzheimer's disease-nested case-control study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Adverse Drug Events in Patients with Dementia and Neuropsychiatric/Behavioral, and Psychological Symptoms, a One-Year Prospective Study.International journal of environmental research and public health · 2019Article
- Chronic Intermittent Hypobaric Hypoxia Ameliorates Renal Vascular Hypertension Through Up-regulating NOS in Nucleus Tractus Solitarii.Neuroscience bulletin · 2019Article
- Adverse effects and non-adherence to antihypertensive medications in University of Gondar Comprehensive Specialized Hospital.Clinical hypertension · 2019Article
- Determinants of community pharmacists' quality of care: a population-based cohort study using pharmacy administrative claims data.BMJ open · 2017Article
- Pharmacological Management of Anxiety Disorders in the Elderly.Current treatment options in psychiatry · 2017Article
- High fat diet confers vascular hyper-contractility against angiotensin II through upregulation of MLCK and CPI-17.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- Age differences in fatigue, decrements in energy, and sleep disturbance in oncology patients receiving chemotherapy.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several guidelines for hypertension have recently undergone revisions to incorporate an approach providing choices of medications based on age, race, and specific situations where hypertension may co-exist with disorders such as diabetes, coronary artery disease, heart failure and chronic kidney disease. Initial recommendations include diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and calcium channel blockers; beta blockers are favored in some guidelines and are a choice in specific settings. Within the classes of drugs, several antihypertensive agents provide options. This review discusses antihypertensive drugs by class, including adverse effects and tolerability, with preferences in older adults and specific settings. Adverse drug events from antihypertensive medications are discussed by class and where applicable for specific agents. Data from select studies pertinent to tolerability and adverse effects are presented in tables for several classes of drugs. The rationale for nonadherence to medication is reviewed, including the roles played by tolerability and adverse drug effects. Antihypertensive therapy in typical settings in older adults is discussed; they include hypertension in association with impaired cognition, depression, diabetes, sexual dysfunction, and falls. The key to successful therapy and tolerability is to promote a healthy lifestyle in conjunction with medications as the approach, thereby also lowering the adverse drug effects. The eventual choice of the specific drug(s) is based on risks, benefits, and patient preferences, and is best tailored for each older adult.
Indexed as
Identifiers
26442857What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.