ArticleAvicenna journal of phytomedicine
Effect of hydro-alcoholic extract of Rosa damascena on cardiovascular responses in normotensive rat.
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Effects of Rosa damascena and its compounds on smooth muscle contractility.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2026Review
- Evaluation of Cardiovascular Effects of the Hydroalcoholic Fruit Extract ofCardiovascular & hematological disorders drug targets · 2026Article
- Review
- Effect ofEvidence-based complementary and alternative medicine : eCAM · 2023Article
- Evaluation of the Phytochemical and Pharmacological Potential of Taif's Rose (Life (Basel, Switzerland) · 2022Article
- Preventive Effect of Hydroalcoholic Extract ofInternational journal of preventive medicine · 2018Article
- Protective impact ofAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRosa damascena mill L. (R. damascena) is a well-known plant with fragrant effects. Several therapeutic effects of this plant on respiratory, gastrointestinal and nervous systems have been reported. It is also suggested to have beneficial effect on cardiovascular system especially blood pressure regulation. The present study was carried out to evaluate acute cardiovascular effect of hydro-alcoholic extract of R. damascena. MATERIALS AND
methodsThirty-two male Wistar rats were randomly divided into four groups (n= 8 for each group). After anesthesia, a catheter was inserted into the femoral artery and blood pressure and heart rate (HR) were continuously recorded by a power lab system. Animals received three doses of hydro-alcoholic extract (250, 500, and 1000 mg/kg) via peritoneal (i.p). After 30 min, systolic blood pressure (SBP), mean arterial pressure (MAP) and HR were recorded and maximal changes were compared to control group.
resultsInjection of all doses of the extract did not significantly change HR compare to control group. The SBP, dose dependently, was decreased by all doses of the extract and the maximal response was significant compared to saline group (p<0.01 to p<0.001). Different doses of the extract also dose-dependently decreased maximal changes of MAP responses compared to control group. The effect of higher doses of the extract on SBP and MAP was significant compared to lower doses (p<0.05 to p<0.01).
conclusionThis study provides evidence of a hypotensive effect of hydro-alcoholic extract of R. damascena with no significant effect on HR. Therefore, R. damascena is suggested to have beneficial effect to control blood pressure. However, it needs to be more investigated.
Indexed as
Identifiers
26442758PMC4587610W1518443581What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.