ReviewAnnual review of psychology2016
Gene × Environment Determinants of Stress- and Anxiety-Related Disorders.
Review in Annual review of psychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 127 citations in OpenAlex.
- Altered Habenula Resting-State Functional Connectivity and Spatial Associations with Neurotransmitter Receptor Distribution of Major Depressive Disorder with and without Anhedonia.Neuropsychiatric disease and treatment · 2026Article
- GHS-R1a signaling drives anxiety-related behavior by shaping excitability of ventromedial hypothalamic neurons.Nature communications · 2025Article
- Prenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behavior.Scientific reports · 2024Article
- Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder.Molecular psychiatry · 2024Review
- Predicting anxiety treatment outcome in community mental health services using linked health administrative data.Scientific reports · 2024Article
- Monoamine Oxidase: A Potential Link in Papez Circuit to Generalized Anxiety Disorders.CNS & neurological disorders drug targets · 2024Review
- Interaction between childhood trauma experience and TPH2 rs7305115 gene polymorphism in brain gray matter volume.Behavioral and brain functions : BBF · 2023Article
- Association of polygenic scores for depression and neuroticism with perceived stress in daily life during a long-lasting stress period.Genes, brain, and behavior · 2023Article
- Endocannabinoid release at ventral hippocampal-amygdala synapses regulates stress-induced behavioral adaptation.Cell reports · 2023Article
- Node of Ranvier remodeling in chronic psychosocial stress and anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Article
- Circuit- and laminar-specific regulation of medial prefrontal neurons by chronic stress.Cell & bioscience · 2023Article
- Review
- Editorial: Case reports in anxiety and stress.Frontiers in psychiatry · 2023Article
- Mining voices from self-expressed messages on social-media: Diagnostics of mental distress during COVID-19.Decision support systems · 2022Article
- Combining S100B and Cytokines as Neuro-Inflammatory Biomarkers for Diagnosing Generalized Anxiety Disorder: A Proof-of-Concept Study Based on Machine Learning.Frontiers in psychiatry · 2022Article
- Gut microbiota in anxiety and depression: Pathogenesis and therapeutics.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Review
- Ankyrin-G Heterozygous Knockout Mice Display Increased Sensitivity to Social Defeat Stress.Complex psychiatry · 2021Article
- From genetics to systems biology of stress-related mental disorders.Neurobiology of stress · 2021Article
- Multiomic biological approaches to the study of child abuse and neglect.Pharmacology, biochemistry, and behavior · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The burgeoning field of gene-by-environment (G×E) interactions has revealed fascinating biological insights, particularly in the realm of stress-, anxiety-, and depression-related disorders. In this review we present an integrated view of the study of G×E interactions in stress and anxiety disorders, including the evolution of genetic association studies from genetic epidemiology to contemporary large-scale genome-wide association studies and G×E studies. We convey the importance of consortia efforts and collaboration to gain the large sample sizes needed to move the field forward. Finally, we discuss several robust and well-reproduced G×E interactions and demonstrate how epidemiological identification of G×E interactions has naturally led to a plethora of basic research elucidating the mechanisms of high-impact genetic variants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.