ArticleInternational journal of preventive medicine2015
Protective Role of Crocin Against Nicotine-induced Damages on Male Mice Liver.
Article in International journal of preventive medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Oral supplementation with crocin (a constituent of saffron) in subjects with cigarette smoking: a clinical trial.Naunyn-Schmiedeberg's archives of pharmacology · 2024Trial
- Hypolipidemic and hepatoprotective effects of corn silk extract in nicotine-administered male mice.Gastroenterology and hepatology from bed to bench · 2024Article
- Renoprotective effects of zinc sulfate against transient liver ischemia/reperfusion injury in rats.Heliyon · 2023Article
- Gallic acid treats dust-induced NAFLD in rats by improving the liver's anti-oxidant capacity and inhibiting ROS/NFκβ/TNFα inflammatory pathway.Iranian journal of basic medical sciences · 2021Article
- The Effects of Crocin on Bone and Cartilage Diseases.Frontiers in pharmacology · 2021Review
- Isolation, purification and characterization of naturally derived Crocetin beta-d-glucosyl ester fromSaudi journal of biological sciences · 2020Article
- Effect ofJournal of diabetes and metabolic disorders · 2019Article
- Effect of crocin on cardiac antioxidants, and hemodynamic parameters after injuries induced by hepatic ischemia-reperfusion in rats.Iranian journal of basic medical sciences · 2019Article
- Effect of Harmine on Nicotine-Induced Kidney Dysfunction in Male Mice.International journal of preventive medicine · 2019Article
- Crocin Prevents Sub-Cellular Organelle Damage, Proteolysis and Apoptosis in Rat Hepatocytes: A Justification for Its Hepatoprotection.Iranian journal of pharmaceutical research : IJPR · 2018Article
- The Effects of Thymoquinone Against Morphine-induced Damages on Male Mice Liver.International journal of preventive medicine · 2018Article
- Renoprotective effect of crocin following liver ischemia/ reperfusion injury in Wistar rats.Iranian journal of basic medical sciences · 2017Article
- Cardioprotective Effect of Crocin Combined with Voluntary Exercise in Rat: Role of Mir-126 and Mir-210 in Heart Angiogenesis.Arquivos brasileiros de cardiologia · 2017Article
- The Hepatoprotective and MicroRNAs Downregulatory Effects of Crocin Following Hepatic Ischemia-Reperfusion Injury in Rats.Oxidative medicine and cellular longevity · 2017Article
- Expression Changes of Apoptotic Genes in Tissues from Mice Exposed to NicotineAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Effect of Genistein on reproductive parameter and serum nitric oxide levels in morphine-treated mice.International journal of reproductive biomedicine · 2016Article
- Gallic acid protects the liver against NAFLD induced by dust exposure and high-fat diet through inhibiting oxidative stress and repressing the inflammatory signaling pathways NF-kβ/TNF-α/IL-6 in Wistar rats.Avicenna journal of phytomedicineArticle
- Ameliorative effects of crocin against electromagnetic field-induced oxidative stress and liver and kidney injuries in mice.Avicenna journal of phytomedicineArticle
- Crocin Improves Damage Induced by Nicotine on A Number of Reproductive Parameters in Male Mice.International journal of fertility & sterilityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNicotine is a major pharmacologically active substance in cigarette smoke. It is mainly metabolized in liver and causes devastating effects. Crocin is the chemical ingredient primarily responsible for the color of saffron. It has different pharmacological effects such as antioxidant and anticancer. This study was designed to evaluate the protective role of crocin against nicotine on the liver of mice.
methodsForty-eight mice were equally divided into 8 groups; control (normal saline), nicotine (2.5 mg/kg), crocin (12.5, 25 and 50 mg/kg) and crocin plus nicotine treated groups. Saline, crocin, nicotine and crocin/nicotine (once a day) were intraperitoneally injected for 4 weeks. The liver weight and histology, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and serum nitric oxide levels have been studied.
resultsThe results indicated that nicotine administration significantly decreased liver weight (48.37%) and increased the mean diameter of hepatocyte (239%), central hepatic vein (28.45%), liver enzymes level (ALP 29.43%, AST 21.81%, ALT 21.55%), and blood serum nitric oxide level (57.18%) compared to saline group (P < 0.05). However, crocin and crocin plus nicotine administration significantly boosted liver weight (49.54%) and decreased the mean diameter of hepatocyte (40.48%), central hepatic vein (15.44%), liver enzymes (ALP 22.02%, AST 19.05%, ALT 23.11%), and nitric oxide levels (35.80%) in all groups compared to nicotine group (percentages represent the maximum dose) (P < 0.05).
conclusionsCrocin showed its partly protective effect against nicotine-induced liver toxicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.