SynthesisClinical cardiology2015
Correlation of the New York Heart Association Classification and the 6-Minute Walk Distance: A Systematic Review.
Synthesis in Clinical cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed.
- The Effect of Vericiguat on Endothelial Function in Patients With Heart Failure With Reduced Ejection Fraction: A Pilot Randomized Study.The American journal of cardiology · 2026Trial
- Clinician-assessed NYHA and EHRA symptom classifications only moderately reflect patient-reported quality of life in heart failure and atrial fibrillation.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026Article
- Validity and Reliability of the Six-Minute Walking Test Compared to Cardiopulmonary Exercise Test in Individuals with Heart Failure Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Predictors of Atrial Fibrillation in Heart Failure Patients with Indications for ICD Implantation.Journal of clinical medicine · 2025Article
- Mental Health Treatment in Adults with Congenital Heart Disease in Germany: An Online, Cross-Sectional Study of Status, Needs, and Treatment Reasons.Journal of cardiovascular development and disease · 2025Article
- Authors' reply to quality of care delivery in patients with acute heart failure.EClinicalMedicine · 2025Article
- Impact of SGLT2 inhibitor on clinical and echocardiographic outcomes in patients with CRT during long-term period.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Assessing the diversity and determinants of health-related quality of life measures in patients with acute heart failure.ESC heart failure · 2024Article
- Misdiagnosis of Chronic Heart Failure in Patients with Type 2 Diabetes Mellitus in Primary Care: A Report of Two Cases and Literature Review.Vascular health and risk management · 2024Review
- Prognostic Role of Metabolic Exercise Testing in Heart Failure.Journal of clinical medicine · 2023Review
- Associations of microcirculation damage on nailfold capillaroscopy with supra-aortic severe ischemic events in patients with Takayasu arteritis.Clinical rheumatology · 2023Article
- Functional assessment based on cardiopulmonary exercise testing in mild heart failure: A multicentre study.ESC heart failure · 2023Article
- Prognostic Value of Combined Biomarkers in Patients With Heart Failure: The Heartmarker Score.Annals of laboratory medicine · 2023Article
- Heart function grading evaluation based on heart sounds and convolutional neural networks.Physical and engineering sciences in medicine · 2023Article
- Use of Sacubitril/Valsartan Prior to Primary Prevention Implantable Cardioverter Defibrillator Implantation.CJC open · 2023Article
- Impact of Mechanical Circulatory Support on Exercise Capacity in Patients With Advanced Heart Failure.Exercise and sport sciences reviews · 2022Article
- Association between heart failure severity and mobility in geriatric patients: an in-clinic study with wearable sensors.Journal of geriatric cardiology : JGC · 2022Article
- Substitute parameters of exercise-induced pulmonary hypertension and usefulness of low workload exercise stress echocardiography in mitral regurgitation.Scientific reports · 2022Article
- Sex Differences in the Relationship between New York Heart Association Functional Classification and Survival in Cardiovascular Disease Patients: A Mediation Analysis of Exercise Capacity with Regular Care Data.Reviews in cardiovascular medicine · 2022Article
- Left atrial remodeling in heart failure: the role of sphericity index (the SPHERICAT-HF study).The international journal of cardiovascular imaging · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFunctional status assessment is the cornerstone of heart failure management and trials. The New York Heart Association (NYHA) classification and 6-minute walk distance (6MWD) are commonly used tools; however, the correlation between them is not well understood. HYPOTHESIS: We hypothesised that the relationship between the NYHA classification and 6MWD might vary across studies.
methodsA systematic literature search was performed to identify all studies reporting both NYHA class and 6MWD. Two reviewers independently assessed study eligibility and extracted data. Thirty-seven studies involving 5678 patients were included.
resultsThere was significant heterogeneity across studies in 6MWD within all NYHA classes: I (n = 16, Q = 934.2; P < 0.001), II (n = 25, Q = 1658.3; P < 0.001), III (n = 30, Q = 1020.1; P < 0.001), and IV (n = 6, Q = 335.5; P < 0.001). There was no significant difference in average 6MWD between NYHA I and II (420 m vs 393 m; P = 0.416). There was a significant difference in average 6MWD between NYHA II and III (393 m vs 321 m; P = 0.014) and III and IV (321 m vs 224 m; P = 0.027). This remained significant after adjusting for region of study, age, and sex.
conclusionsAlthough there is an inverse correlation between NYHA II-IV and 6MWD, there is significant heterogeneity across studies in 6MWD within each NYHA class and overlap in 6MWD between NYHA I and II. The NYHA classification performs well in more symptomatic patients (NYHA III/IV) but less so in asymptomatic/mildly symptomatic patients (NYHA I/II). Nonetheless, the NYHA classification is an easily applied first-line tool in everyday clinical practice, but its potential subjectivity should be considered when performing comparisons across studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.