ArticleEpigenomics2015
Monocyte enhancers are highly altered in systemic lupus erythematosus.
Article in Epigenomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Genetic variants differentially associated with rheumatoid arthritis and systemic lupus erythematosus reveal the disease-specific biology.Scientific reports · 2019Pooled it
- An Update Comprehensive Review on Epigenetic Modifications and Therapies in Autoimmune Diseases.Clinical reviews in allergy & immunology · 2026Review
- IL-10 targets IRF transcription factors to suppress IFN and inflammatory response genes by epigenetic mechanisms.Nature immunology · 2025Article
- Comparison of cell type and disease subset chromatin modifications in SLE.Clinical epigenetics · 2024Article
- Autoimmune diseases and atherosclerotic cardiovascular disease.Nature reviews. Cardiology · 2024Review
- Targeting aryl hydrocarbon receptor functionally restores tolerogenic dendritic cells derived from patients with multiple sclerosis.The Journal of clinical investigation · 2024Article
- Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition.Rheumatology (Oxford, England) · 2023Article
- Deciphering the Molecular Mechanism of Flares in Patients with Systemic Lupus Erythematosus through Single-Cell Transcriptome Analysis of the Peripheral Blood.Mediterranean journal of rheumatology · 2022Article
- Article
- Transcriptomics and quantitative proteomics reveal changes after second stimulation of bone marrow-derived macrophages from lupus-prone MRL/lpr mice.Frontiers in immunology · 2022Article
- Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses.PLoS pathogens · 2021Review
- IL-1 Transcriptional Responses to Lipopolysaccharides Are Regulated by a Complex of RNA Binding Proteins.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Insights into rheumatic diseases from next-generation sequencing.Nature reviews. Rheumatology · 2019Review
- Enhancer RNA and NFκB-dependent P300 regulation of ADAMDEC1.Molecular immunology · 2018Article
- Overall Downregulation of mRNAs and Enrichment of H3K4me3 Change Near Genome-Wide Association Study Signals in Systemic Lupus Erythematosus: Cell-Specific Effects.Frontiers in immunology · 2018Article
- The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders.Frontiers in immunology · 2018Review
- Review: Enhancers in Autoimmune Arthritis: Implications and Therapeutic Potential.Arthritis & rheumatology (Hoboken, N.J.) · 2017Review
- SERPINB2 is regulated by dynamic interactions with pause-release proteins and enhancer RNAs.Molecular immunology · 2017Article
- Chromatin landscapes and genetic risk in systemic lupus.Arthritis research & therapy · 2016Article
- New insights into the immunopathogenesis of systemic lupus erythematosus.Nature reviews. Rheumatology · 2016Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveHistone modifications set transcriptional competency and can perpetuate pathologic expression patterns. We defined systemic lupus erythematosus (SLE)-specific changes in H3K4me3 and K3K27me3, histone marks of gene activation and repression, respectively.
methodsWe used ChIP-seq to define histone modifications in monocytes from SLE patients and controls.
resultsBoth promoters and enhancers exhibited significant changes in histone methylation in SLE. Regions with differential H3K4me3 in SLE were significantly enriched in potential interferon-related transcription factor binding sites and pioneer transcription factor sites.
conclusionEnhancer activation defines the character of the cell and our data support extensive disease effects in monocytes, a particularly plastic lineage. Type I interferons not only drive altered gene expression but may also alter the character of the cell through chromatin modifications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.