ArticleFrontiers in genetics2015
Molecular footprinting of skeletal tissues in the catshark Scyliorhinus canicula and the clawed frog Xenopus tropicalis identifies conserved and derived features of vertebrate calcification.
Article in Frontiers in genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Reappraisal of the extinct barbelthroat shark †Bavariscyllium and the nebulous origin of carcharhiniform galeomorphs.Communications biology · 2026Article
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- Cellular, bone-like tissue in the bucklers and thorns of the thornback rayProceedings. Biological sciences · 2025Article
- A Comprehensive Analysis of Fibrillar Collagens in Lamprey Suggests a Conserved Role in Vertebrate Musculoskeletal Evolution.Frontiers in cell and developmental biology · 2022Article
- Evolution of Matrix Gla and Bone Gla Protein Genes in Jawed Vertebrates.Frontiers in genetics · 2021Article
- Divergent Expression ofFrontiers in genetics · 2021Article
- Mineralized Cartilage and Bone-Like Tissues in Chondrichthyans Offer Potential Insights Into the Evolution and Development of Mineralized Tissues in the Vertebrate Endoskeleton.Frontiers in genetics · 2021Review
- Endoskeletal mineralization in chimaera and a comparative guide to tessellated cartilage in chondrichthyan fishes (sharks, rays and chimaera).Journal of the Royal Society, Interface · 2020Article
- Article
- Mineralization of theFrontiers in genetics · 2020Article
- Skeletal Mineralization in Association with Type X Collagen Expression Is an Ancestral Feature for Jawed Vertebrates.Molecular biology and evolution · 2019Article
- Evolution of dental tissue mineralization: an analysis of the jawed vertebrate SPARC and SPARC-L families.BMC evolutionary biology · 2018Article
- Evolutionary origin of endochondral ossification: the transdifferentiation hypothesis.Development genes and evolution · 2017Review
- Ultrastructural and developmental features of the tessellated endoskeleton of elasmobranchs (sharks and rays).Journal of anatomy · 2016Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the evolutionary emergence and subsequent diversification of the vertebrate skeleton requires a comprehensive view of the diverse skeletal cell types found in distinct developmental contexts, tissues, and species. To date, our knowledge of the molecular nature of the shark calcified extracellular matrix, and its relationships with osteichthyan skeletal tissues, remain scarce. Here, based on specific combinations of expression patterns of the Col1a1, Col1a2, and Col2a1 fibrillar collagen genes, we compare the molecular footprint of endoskeletal elements from the chondrichthyan Scyliorhinus canicula and the tetrapod Xenopus tropicalis. We find that, depending on the anatomical location, Scyliorhinus skeletal calcification is associated to cell types expressing different subsets of fibrillar collagen genes, such as high levels of Col1a1 and Col1a2 in the neural arches, high levels of Col2a1 in the tesserae, or associated to a drastic Col2a1 downregulation in the centrum. We detect low Col2a1 levels in Xenopus osteoblasts, thereby revealing that the osteoblastic expression of this gene was significantly reduced in the tetrapod lineage. Finally, we uncover a striking parallel, from a molecular and histological perspective, between the vertebral cartilage calcification of both species and discuss the evolutionary origin of endochondral ossification.
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