ArticleFrontiers in plant science2015
The polyamine spermine induces the unfolded protein response via the MAPK cascade in Arabidopsis.
Article in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Using animal models to decipher the role of polyamines in the pancreas and β Cell.Amino acids · 2026Review
- Melatonin and Abiotic Stress Tolerance in Crop Plants.International journal of molecular sciences · 2023Review
- TcbZIP60 positively regulates pyrethrins biosynthesis inFrontiers in plant science · 2023Article
- Lipid kinases PIP5K7 and PIP5K9 are required for polyamine-triggered KThe Plant journal : for cell and molecular biology · 2020Article
- The Multifaceted Roles of Plant Hormone Salicylic Acid in Endoplasmic Reticulum Stress and Unfolded Protein Response.International journal of molecular sciences · 2019Review
- Spermine Induces Autophagy in Plants: Possible Role of NO and Reactive Oxygen Species.Doklady. Biochemistry and biophysics · 2018Article
- Polyamine Metabolism and Oxidative Protein Folding in the ER as ROS-Producing Systems Neglected in Virology.International journal of molecular sciences · 2018Review
- Ornithine Decarboxylase-Mediated Production of Putrescine Influences Ganoderic Acid Biosynthesis by Regulating Reactive Oxygen Species in Ganoderma lucidum.Applied and environmental microbiology · 2017Article
- Spermine modulates the expression of two probable polyamine transporter genes and determines growth responses to cadaverine in Arabidopsis.Plant cell reports · 2016Article
- Calcium-Mediated Abiotic Stress Signaling in Roots.Frontiers in plant science · 2016Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Arabidopsis three basic region leucine zipper (bZIP) transcription factor genes, bZIP17, bZIP28, and bZIP60, play crucial roles in the unfolded protein response (UPR). Previously we found that bZIP60 is one of the spermine-induced genes. Consequently we further investigated the response of all the three bZIP genes to spermine. Expression of bZIP17, bZIP28, and bZIP60, and also their target genes was activated by spermine application as well as in plants with elevated endogenous spermine levels. Furthermore, spermine activated the splicing of the bZIP60 transcript mediated by the ribonuclease activity of inositol-requiring enzyme 1 and also recruited bZIP17 and bZIP60 proteins from endoplasmic reticulum to nucleus. We therefore propose that spermine is a novel UPR inducer. Moreover, induction of UPR by spermine required calcium-influx to the cytoplasm and the genes for mitogen-activated protein kinase kinase 9 (MKK9), mitogen-activated protein kinase 3 (MPK3) and MPK6. The result indicates that spermine-induced UPR is mediated by the MKK9-MPK3/MPK6 cascade in Arabidopsis.
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