ArticleFrontiers in microbiology2015
Exploring antibiotic resistance genes and metal resistance genes in plasmid metagenomes from wastewater treatment plants.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 166 citations in OpenAlex.
- Article
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- Dynamic changes in the plasmidome and resistome in the gastrointestinal tract of chickens.Microbiology spectrum · 2026Article
- Diverse microbial metal resistance and novel metal cycling organisms in copper/nickel mine tailings.Metallomics : integrated biometal science · 2026Article
- Beyond borders: plasmids drive a shared antibiotic resistome in European urban water systems.Microbiome · 2026Article
- Relative abundance of heavy metal resistance genes of three drinking water treatment plants unveiled through shotgun metagenomics.Frontiers in microbiology · 2026Article
- Occurrence of Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2025Article
- Communities of plasmids as strategies for antimicrobial resistance gene survival in wastewater treatment plant effluent.npj antimicrobials and resistance · 2025Article
- MOSTPLAS: a self-correction multi-label learning model for plasmid host range prediction.Bioinformatics (Oxford, England) · 2025Article
- Sludge water: a potential pathway for the spread of antibiotic resistance and pathogenic bacteria from hospitals to the environment.Frontiers in microbiology · 2025Article
- The Role of Wastewater Treatment Plants in Dissemination of Antibiotic Resistance: Source, Measurement, Removal and Risk Assessment.Antibiotics (Basel, Switzerland) · 2024Review
- Contrary effects of increasing temperatures on the spread of antimicrobial resistance in river biofilms.mSphere · 2024Article
- Emergence of Carbapenemase Genes in Gram-Negative Bacteria Isolated from the Wastewater Treatment Plant in A Coruña, Spain.Antibiotics (Basel, Switzerland) · 2024Article
- The microbiome, resistome, and their co-evolution in sewage at a hospital for infectious diseases in Shanghai, China.Microbiology spectrum · 2024Article
- Inter-plasmid transfer of antibiotic resistance genes accelerates antibiotic resistance in bacterial pathogens.The ISME journal · 2024Article
- Shotgun Metagenomics-Guided Prediction Reveals the Metal Tolerance and Antibiotic Resistance of Microbes in Poly-Extreme Environments in the Danakil Depression, Afar Region.Antibiotics (Basel, Switzerland) · 2023Article
- Multilayer networks of plasmid genetic similarity reveal potential pathways of gene transmission.The ISME journal · 2023Article
- Comparison of long- and short-read metagenomic assembly for low-abundance species and resistance genes.Briefings in bioinformatics · 2023Article
- Effects of chronic exposure to arsenic on the fecal carriage of antibiotic-resistant Escherichia coli among people in rural Bangladesh.PLoS pathogens · 2022Article
- Bacterial Resistance to β-Lactam Antibiotics in Municipal Wastewater: Insights from a Full-Scale Treatment Plant in Poland.Microorganisms · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasmids operate as independent genetic elements in microorganism communities. Through horizontal gene transfer (HGT), they can provide their host microorganisms with important functions such as antibiotic resistance and heavy metal resistance. In this study, six metagenomic libraries were constructed with plasmid DNA extracted from influent, activated sludge (AS) and digested sludge (DS) of two wastewater treatment plants (WWTPs). Compared with the metagenomes of the total DNA extracted from the same sectors of the wastewater treatment plant, the plasmid metagenomes had significantly higher annotation rates, indicating that the functional genes on plasmids are commonly shared by those studied microorganisms. Meanwhile, the plasmid metagenomes also encoded many more genes related to defense mechanisms, including ARGs. Searching against an antibiotic resistance genes (ARGs) database and a metal resistance genes (MRGs) database revealed a broad-spectrum of antibiotic (323 out of a total 618 subtypes) and MRGs (23 out of a total 23 types) on these plasmid metagenomes. The influent plasmid metagenomes contained many more resistance genes (both ARGs and MRGs) than the AS and the DS metagenomes. Sixteen novel plasmids with a complete circular structure that carried these resistance genes were assembled from the plasmid metagenomes. The results of this study demonstrated that the plasmids in WWTPs could be important reservoirs for resistance genes, and may play a significant role in the horizontal transfer of these genes.
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