ArticleFrontiers in microbiology2015
Attributes of carbapenemase encoding conjugative plasmid pNDM-SAL from an extensively drug-resistant Salmonella enterica Serovar Senftenberg.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 30 citations in OpenAlex.
- Successful treatment of an NDM-5-producing, carbapenem-resistant Salmonella Kentucky ST198 infection with aztreonam and ceftazidime-avibactam in a patient with acute erythroid leukemia: a case report.BMC infectious diseases · 2026Article
- Whole genome-sequence-based molecular characterisation of Salmonella Kentucky co-resistant to fluoroquinolones and cephalosporins isolated from children during 2017 to 2024: emergence of blaBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Genomic portrayal of emerging carbapenem-resistant El Tor variantAntimicrobial agents and chemotherapy · 2025Article
- First Report in the Americas ofAntibiotics (Basel, Switzerland) · 2025Article
- ISiScience · 2025Article
- The emergence of carbapenem-resistance and New Delhi metallo-β-lactamase-1 (Iranian journal of microbiology · 2024Article
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- Characterization of NDM-5 Carbapenemase-Encoding Gene (Infection and drug resistance · 2022Article
- Replication of the Salmonella Genomic Island 1 (SGI1) triggered by helper IncC conjugative plasmids promotes incompatibility and plasmid loss.PLoS genetics · 2020Article
- Resistance ofFrontiers in microbiology · 2020Article
- Extensive drug resistant Salmonella enterica serovar Senftenberg carrying blaPathogens and global health · 2019Article
- Altered Integrative and Conjugative Elements (ICEs) in RecentFrontiers in microbiology · 2019Article
- Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food.Veterinary sciences · 2018Review
- Genomic characterization of a large plasmid containing a blaBMC infectious diseases · 2017Article
- Identification of IncA/C Plasmid Replication and Maintenance Genes and Development of a Plasmid Multilocus Sequence Typing Scheme.Antimicrobial agents and chemotherapy · 2017Article
- The rapid spread of carbapenem-resistant Enterobacteriaceae.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2016Review
- Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
A carbapenem resistant Salmonella enterica serovar Senftenberg isolate BCH 2406 was isolated from a diarrheal child attending an outpatient unit of B.C. Roy Hospital in Kolkata, India. This isolate was positive for the bla NDM-1 in the PCR assay, which was confirmed by amplicon sequencing. Except for tetracycline, this isolate was resistant to all the tested antimicrobials. The bla NDM-1 was found to be located on a 146.13-kb mega plasmid pNDM-SAL, which could be conjugally transferred into Escherichia coli and other enteric pathogens such as Vibrio cholerae O1 Ogawa and Shigella flexneri 2a. However, the expression of β-lactam resistance is not the same in different bacteria. The whole genome sequence of pNDM-SAL was determined and compared with other pNDM plasmids available in public domain. This plasmid is an IncA/C incompatibility type composed of 155 predicted coding sequences and shares homology with plasmids of E. coli pNDM-1_Dok01, Klebsiella pNDM-KN, and Citrobacter pNDM-CIT. In pNDM-SAL, gene cluster containing bla NDM-1 was located between IS26 and IS4321 elements. Between the IS26 element and the bla NDM-1, a truncated ISAba125 insertion sequence was identified. Downstream of the bla NDM-1, other genes, such as ble MBL, trpF, tat, and an ISCR1 element with class 1 integron containing aac(6')-Ib were detected. Another β-lactacamase gene, bla CMY -4 was found to be inserted in IS1 element within the type IV conjugative transfer loci of the plasmid. This gene cluster had blc and sugE downstream of the bla CMY -4. From our findings, it appears that the strain S. Senftenberg could have acquired the NDM plasmid from the other members of Enterobacteriaceae. Transfer of NDM plasmids poses a danger in the management of infectious diseases.
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