ArticleFrontiers in microbiology2015
Prevalence and distribution of soil-borne zoonotic pathogens in Lahore district of Pakistan.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Coxiella burnetii in Pakistan: a meta-analysis.BMC veterinary research · 2025Pooled it
- Prevalence and Risk Factors of Coxiellosis at the Human-Animal-Environment Interface in the South Asian Countries: A Systematic Review and Meta-Analysis.Transboundary and emerging diseases · 2025Pooled it
- Epidemiology of tularemia in the countries of the WHO Eastern Mediterranean Region (EMRO): A systematic review and meta-analysis.PLoS neglected tropical diseases · 2024Pooled it
- Genomic reconstruction ofMicrobial genomics · 2025Article
- Identifying key soil characteristics for Francisella tularensis classification with optimized Machine learning models.Scientific reports · 2024Article
- Molecular detection ofFrontiers in microbiology · 2023Article
- Sero-Epidemiology ofPathogens (Basel, Switzerland) · 2022Article
- One Health Paradigm to Confront Zoonotic Health Threats: A Pakistan Prospective.Frontiers in microbiology · 2021Review
- The prevalence ofIranian journal of microbiology · 2019Article
- Melioidosis in South Asia (India, Nepal, Pakistan, Bhutan and Afghanistan).Tropical medicine and infectious disease · 2018Review
- Subterranean Mammals: Reservoirs of Infection or Overlooked Sentinels of Anthropogenic Environmental Soiling?EcoHealth · 2017Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A multidisciplinary, collaborative project was conducted to determine the prevalence and distribution of soil-borne zoonotic pathogens in Lahore district of Pakistan and ascertain its Public Health Significance. Using a grid-based sampling strategy, soil samples (n = 145) were collected from villages (n = 29, 5 samples/village) and examined for Bacillus anthracis, Burkholderia mallei/pseudomallei, Coxiella burnetii, Francisella tularensis, and Yersinia pestis using real time PCR assays. Chemical analysis of soil samples was also performed on these samples. The relationship between soil composition and absence or presence of the pathogen, and seven risk factors was evaluated. DNA of B. anthracis (CapB), B. mallei/pseudomallei (chromosomal gene), C. burnetii (IS1111, transposase gene), and F. tularensis (lipoprotein/outer membrane protein) was detected in 9.6, 1.4, 4.8, and 13.1% of soil samples, respectively. None of the samples were positive for protective antigen plasmid (PA) of B. anthracis and Y. pestis (plasminogen activating factor, pPla gene). The prevalence of B. anthracis (CapB) was found to be associated with organic matter, magnesium (Mg), copper (Cu), chromium (Cr), manganese (Mn), cobalt (Co), cadmium (Cd), sodium (Na), ferrous (Fe), calcium (Ca), and potassium (K). Phosphorous (P) was found to be associated with prevalence of F. tularensis while it were Mg, Co, Na, Fe, Ca, and K for C. burnetii. The odds of detecting DNA of F. tularensis were 2.7, 4.1, and 2.7 higher when soil sample sites were >1 km from animal markets, >500 m from vehicular traffic roads and animal density of < 1000 animals, respectively. While the odds of detecting DNA of C. burnetii was 32, 11.8, and 5.9 higher when soil sample sites were >500 m from vehicular traffic roads, presence of ground cover and animal density of < 1000 animals, respectively. In conclusion, the distribution pattern of the soil-borne pathogens in and around the areas of Lahore district puts both human and animal populations at a high risk of exposure. Further studies are needed to explore the genetic nature and molecular diversity of prevailing pathogens together with their seroconversion in animals and humans.
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