ArticleFrontiers in microbiology2015
Filamentous fungi from extreme environments as a promising source of novel bioactive secondary metabolites.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 105 citations in OpenAlex.
- Pigmented fungi derived from hot and cold deserts ecosystems: taxonomy, genomic and biotechnological approach.World journal of microbiology & biotechnology · 2026Review
- Gradients of Aliveness and Engineering: A Taxonomy of Fungal Engineered Living Materials.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Bio-guided discovery of antibacterial metabolites fromJournal of enzyme inhibition and medicinal chemistry · 2025Article
- Bioprospecting bioactive metabolites from Aspergillus fumigatus: identification, culture optimization, spectroscopic profiling, and evaluation of antifungal and antioxidant potential.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Native Fungi as a Nature-Based Solution to Mitigate Toxic Metal(loid) Accumulation in Rice.Microorganisms · 2025Article
- Comprehensive analysis of 42 psilocybin-producing fungal strains reveals metabolite diversity and species-specific clusters.Scientific reports · 2025Article
- New Secondary Metabolites of Mangrove-Associated Strains.Marine drugs · 2024Review
- The Cytotoxic Properties of Extreme Fungi's Bioactive Components-An Updated Metabolic and Omics Overview.Life (Basel, Switzerland) · 2023Review
- Characterization and metabolomic profiling of two pigment producing fungi from infected fruits of Indian Gooseberry.Archives of microbiology · 2023Article
- Biodiversity and Bioprospecting of Fungal Endophytes from the Antarctic PlantJournal of fungi (Basel, Switzerland) · 2022Article
- Fungal-fungal co-culture: a primer for generating chemical diversity.Natural product reports · 2022Review
- Metabolic Potential of Halophilic Filamentous Fungi-Current Perspective.International journal of molecular sciences · 2022Review
- Marine fungi showing multifunctional activity against human pathogenic microbes and cancer.PloS one · 2022Article
- Editorial: Fungal Bioactive Metabolites of Pharmacological Relevance.Frontiers in pharmacology · 2022Article
- Epigenetic Activation of Silent Biosynthetic Gene Clusters in Endophytic Fungi Using Small Molecular Modifiers.Frontiers in microbiology · 2022Review
- A review on the potential of filamentous fungi for microbial self-healing of concrete.Fungal biology and biotechnology · 2021Review
- Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds.Journal of fungi (Basel, Switzerland) · 2021Review
- Trends and Applications of Omics Technologies to Functional Characterisation of Enzymes and Protein Metabolites Produced by Fungi.Journal of fungi (Basel, Switzerland) · 2021Review
- Diversity, Ecological Role and Biotechnological Potential of Antarctic Marine Fungi.Journal of fungi (Basel, Switzerland) · 2021Review
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Corrections and comments
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural product search is undergoing resurgence upon the discovery of a huge previously unknown potential for secondary metabolite (SM) production hidden in microbial genomes. This is also the case for filamentous fungi, since their genomes contain a high number of "orphan" SM gene clusters. Recent estimates indicate that only 5% of existing fungal species have been described, thus the potential for the discovery of novel metabolites in fungi is huge. In this context, fungi thriving in harsh environments are of particular interest since they are outstanding producers of unusual chemical structures. At present, there are around 16 genomes from extreme environment-isolated fungi in databases. In a preliminary analysis of three of these genomes we found that several of the predicted SM gene clusters are probably involved in the biosynthesis of compounds not yet described. Genome mining strategies allow the exploitation of the information in genome sequences for the discovery of new natural compounds. The synergy between genome mining strategies and the expected abundance of SMs in fungi from extreme environments is a promising path to discover new natural compounds as a source of medically useful drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.