ReviewFrontiers in endocrinology2015
Regulation and Function of RFRP-3 (GnIH) Neurons during Postnatal Development.
Review in Frontiers in endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Divergent Photoperiodic Responses in HypothalamicAnimals : an open access journal from MDPI · 2025Article
- GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147.Bone research · 2025Article
- The Role of RFRP Neurons in the Allostatic Control of Reproductive Function.International journal of molecular sciences · 2023Review
- Impact of stress on male fertility: role of gonadotropin inhibitory hormone.Frontiers in endocrinology · 2023Review
- Variation in Hypothalamic GnIH Expression and Its Association withAnimals : an open access journal from MDPI · 2022Article
- RF-amide related peptide-3 (RFRP-3): a novel neuroendocrine regulator of energy homeostasis, metabolism, and reproduction.Molecular biology reports · 2021Review
- Gonadotropin Inhibitory Hormone and Its Receptor: Potential Key to the Integration and Coordination of Metabolic Status and Reproduction.Frontiers in endocrinology · 2021Review
- Ontogenetic and tissue-specific expression of gonadotropin-inhibitory hormone (GnIH) and its receptors in Catla catla.Molecular biology reports · 2020Article
- The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction.Iranian journal of basic medical sciences · 2018Review
- Emerging insights into hypothalamic-pituitary-gonadal axis regulation and interaction with stress signalling.Journal of neuroendocrinology · 2018Review
- Sex- and brain region-specific patterns of gene expression associated with socially-mediated puberty in a eusocial mammal.PloS one · 2018Article
- Is precocious puberty linked to hypothalamic expression of arginine-phenylalanine-amide-related peptide?Iranian journal of basic medical sciences · 2017Review
- Intracerebroventricular injection of RFRP-3 delays puberty onset and stimulates growth hormone secretion in female rats.Reproductive biology and endocrinology : RB&E · 2017Article
- Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex?Brain research · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
RFamide-related peptide-3 (RFRP-3) [mammalian ortholog to gonadotropin-inhibiting hormone (GnIH)] potently inhibits gonadotropin secretion in mammals. Studies of RFRP-3 immunoreactivity and Rfrp expression (the gene encoding RFRP-3) in mammalian brains have uncovered several possible pathways regulating RFRP-3 neurons, shedding light on their potential role in reproduction and other processes, and pharmacological studies have probed the target sites of RFRP-3 action. Despite this, there is currently no major consensus on RFRP-3's specific endogenous role(s) in reproductive physiology. Here, we discuss the latest evidence relating to RFRP-3 neuron regulation and function during development and sexual maturation, focusing on rodents. We highlight significant changes in RFRP-3 and Rfrp expression, as well as RFRP-3 neuronal activation, during key stages of postnatal and pubertal development and also discuss recent evidence testing the requisite role of RFRP-3 receptors for normal pubertal timing and developmental LH secretion. Interestingly, some findings suggest that endogenous RFRP-3 signaling may not be necessary for the puberty timing, at least in some species, forcing new hypotheses to be generated regarding this peptide's functional significance to sexual maturation and development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.