Evidence map›Paper›PMID 26441664›Full record

ArticleFrontiers in pharmacology2015

Developing multi-target therapeutics to fine-tune the evolutionary dynamics of the cancer ecosystem.

Lei Xie, Philip E Bourne

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Phytochemicals Target Multiple Metabolic Pathways in Cancer.Antioxidants (Basel, Switzerland) · 2023
    Review
  3. Synthesis of novel spirochromane incorporating Schiff's bases, potential antiproliferative activity, and dual EGFR/HER2 inhibition: Cell cycle analysis andSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
  4. Article
  5. Article
  6. 5,8-Dimethyl-9Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Synthesis of some quinazolinones inspired from the natural alkaloid LJournal of enzyme inhibition and medicinal chemistry · 2021
    Article
  12. Review
  13. Recent Advances in Oligonucleotide Therapeutics in Oncology.International journal of molecular sciences · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lei XieDepartment of Computer Science, Hunter College, The City University of New York New York, NY, USA ; The Graduate Center, The City University of New York New York, NY, USA.
Philip E BourneOffice of the Director, National Institutes of Health Bethesda, MD, USA.

Funding

Structural Bioinformatics, Systems Pharmacology and Scholarly CommunicationZIALM000928 · NLM · NATIONAL LIBRARY OF MEDICINE · PI BOURNE, PHILIP · 2015 to 2016
$1.3M
Drug discovery by integrating chemical genomics and structural systems biologyR01LM011986 · NLM · HUNTER COLLEGE · PI BRINKMAN, FIONA, BURLEY, STEPHEN K · 2014 to 2017
$1.2M
NLM NIH HHS R01 LM011986
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cancer evolutioncell-cell communicationmulti-target drugnon-linear dynamic systempolypharmacology

Identifiers

PMID26441664
PMCPMC4585080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.