ArticleFrontiers in computational neuroscience2015
Modeling spontaneous activity across an excitable epithelium: Support for a coordination scenario of early neural evolution.
Article in Frontiers in computational neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Neural connectome of the ctenophore statocyst.eLife · 2026Article
- Dynamics of neural activity in early nervous system evolution.Current opinion in behavioral sciences · 2024Article
- Active oscillations in microscale navigation.Animal cognition · 2023Review
- Cellular Competency during Development Alters Evolutionary Dynamics in an Artificial Embryogeny Model.Entropy (Basel, Switzerland) · 2023Article
- Modelling the effects of short and random proto-neural elongations.Journal of the Royal Society, Interface · 2017Article
- Is Empiricism Empirically False? Lessons from Early Nervous Systems.Biosemiotics · 2017Article
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4 authors.
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Abstract
Internal coordination models hold that early nervous systems evolved in the first place to coordinate internal activity at a multicellular level, most notably the use of multicellular contractility as an effector for motility. A recent example of such a model, the skin brain thesis, suggests that excitable epithelia using chemical signaling are a potential candidate as a nervous system precursor. We developed a computational model and a measure for whole body coordination to investigate the coordinative properties of such excitable epithelia. Using this measure we show that excitable epithelia can spontaneously exhibit body-scale patterns of activation. Relevant factors determining the extent of patterning are the noise level for exocytosis, relative body dimensions, and body size. In smaller bodies whole-body coordination emerges from cellular excitability and bidirectional excitatory transmission alone. Our results show that basic internal coordination as proposed by the skin brain thesis could have arisen in this potential nervous system precursor, supporting that this configuration may have played a role as a proto-neural system and requires further investigation.
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