Evidence map›Paper›PMID 26441610›Full record

ArticleFrontiers in human neuroscience2015

Recovery of resting brain connectivity ensuing mild traumatic brain injury.

Rose D Bharath, Ashok Munivenkatappa, Suril Gohel, Rajanikant Panda, Jitender Saini, Jamuna Rajeswaran, Dhaval Shukla, Indira D Bhagavatula, Bharat B Biswal

Abstract read
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In one paragraph

Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rose D BharathAdvanced Brain Imaging Facility, Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences Bangalore, India ; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences Bangalore, India.
Ashok MunivenkatappaDepartment of Clinical Neurosciences, National Institute of Mental Health and Neurosciences Bangalore, India.
Suril GohelDepartment of Biomedical Engineering, New Jersey Institute of Technology, University Heights Newark, NJ, USA.
Rajanikant PandaAdvanced Brain Imaging Facility, Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences Bangalore, India ; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences Bangalore, India.
Jitender SainiDepartment of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences Bangalore, India.
Jamuna RajeswaranNeuropsychology Unit, Department of Clinical Psychology, National Institute of Mental Health and Neurosciences Bangalore, India.
Dhaval ShuklaDepartment of Neurosurgery, National Institute of Mental Health and Neurosciences Bangalore, India.
Indira D BhagavatulaDepartment of Neurosurgery, National Institute of Mental Health and Neurosciences Bangalore, India.
Bharat B BiswalDepartment of Biomedical Engineering, New Jersey Institute of Technology, University Heights Newark, NJ, USA.

Funding

Functional MRI of Aging: Biophysical CharacterizationR01AG032088 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI BISWAL, BHARAT BHUSAN · 2010 to 2014
$1.5M
NIA NIH HHS R01 AG032088
6 · The paper itself

Abstract

Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in patients recovering from mild traumatic brain injury (mTBI). Twenty-five subjects with mild head injury were longitudinally evaluated within 36 h, 3 and 6 months using resting state functional connectivity (RSFC). Region of interest (ROI) based connectivity differences over time within the patient group and in comparison with a healthy control group were analyzed at p < 0.005. We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time. Within 3 months, the majority of the ROI pairs had decreased connectivity in mTBI population, which increased and became comparable to healthy controls at 6 months. Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections. This hyper connectivity involved the salience network and default mode network within 36 h, and lingual, inferior frontal and fronto-parietal networks at 3 months. Our findings in a fairly homogenous group of patients with mTBI evaluated during the 6 month window of recovery defines time varying brain connectivity changes as the brain recovers from an injury. A majority of these changes were seen in the frontal and parietal lobes between 3 and 6 months after injury. Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.

Indexed as

brain plasticityhyper connectivitylongitudinal studymild traumatic brain injuryresting state functional connectivitytime varying changes

Identifiers

PMID26441610
PMCPMC4585122

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.