Evidence map›Paper›PMID 26441609›Full record

ArticleFrontiers in human neuroscience2015

Task-related activity in sensorimotor cortex in Parkinson's disease and essential tremor: changes in beta and gamma bands.

Nathan C Rowland, Coralie De Hemptinne, Nicole C Swann, Salman Qasim, Svjetlana Miocinovic, Jill L Ostrem, Robert T Knight, Philip A Starr

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In one paragraph

Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nathan C RowlandDepartment of Neurological Surgery, University of California, San Francisco San Francisco, CA, USA.
Coralie De HemptinneDepartment of Neurological Surgery, University of California, San Francisco San Francisco, CA, USA.
Nicole C SwannDepartment of Neurological Surgery, University of California, San Francisco San Francisco, CA, USA.
Salman QasimDepartment of Neurological Surgery, University of California, San Francisco San Francisco, CA, USA.
Svjetlana MiocinovicDepartment of Neurology, University of California, San Francisco San Francisco, CA, USA.
Jill L OstremDepartment of Neurology, University of California, San Francisco San Francisco, CA, USA.
Robert T KnightDepartment of Neurological Surgery, University of California, San Francisco San Francisco, CA, USA ; Department of Neurology, University of California, San Francisco San Francisco, CA, USA ; Helen Wills Neuroscience Institute, University of California, Berkeley Berkeley, CA, USA ; Department of Psychology, University of California, Berkeley Berkeley, CA, USA.
Philip A StarrDepartment of Neurological Surgery, University of California, San Francisco San Francisco, CA, USA.

Funding

ATTENTION, ORIENTATION, & THE HUMAN PREFRONTAL CORTEXR37NS021135 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI KNIGHT, ROBERT THOMAS · 2013 to 2019
$3.6M
Cortical and basal ganglia local field potentials in human movement disordersR01NS069779 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STARR, PHILIP ANDREW · 2010 to 2012
$1.0M
Cortical Activation in Parkinson's Disease During a Cued Arm Movement TaskF32NS083240 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROWLAND, NATHAN C. · 2013 to 2013
$50k
NINDS NIH HHS F32 NS083240NINDS NIH HHS R01 NS069779NINDS NIH HHS R37 NS021135
6 · The paper itself

Abstract

In Parkinson's disease patients in the OFF medication state, basal ganglia local field potentials exhibit changes in beta and gamma oscillations that correlate with reduced voluntary movement, manifested as rigidity and akinesia. However, magnetoencephalography and low-resolution electrocorticography (ECoG) studies in Parkinson's patients suggest that changes in sensorimotor cortical oscillations differ from those of the basal ganglia. To more clearly define the role of sensorimotor cortex oscillatory activity in Parkinson's, we performed intraoperative, high-resolution (4 mm spacing) ECoG recordings in 10 Parkinson's patients (2 females, ages 47-72) undergoing deep brain stimulation (DBS) lead placement in the awake, OFF medication state. We analyzed ECoG potentials during a computer-controlled reaching task designed to separate movement preparation from movement execution and compared findings to similar invasive recordings in eight patients with essential tremor (3 females, ages 59-78), a condition not associated with rigidity or akinesia. We show that (1) cortical beta spectral power at rest does not differ between Parkinson's and essential tremor patients (p = 0.85), (2) early motor preparation in Parkinson's patients in the OFF medication state is associated with a larger beta desynchronization compared to patients with essential tremor (p = 0.0061), and (3) cortical broadband gamma power is elevated in Parkinson's patients compared to essential tremor patients during both rest and task recordings (p = 0.004). Our findings suggest an oscillatory profile in sensorimotor cortex of Parkinson's patients that, in contrast to the basal ganglia, may act to promote movement to oppose the anti-kinetic bias of the dopamine-depleted state.

Indexed as

beta frequencydeep brain stimulationelectrocorticographyessential tremoripadoscillationsParkinson's disease

Identifiers

PMID26441609
PMCPMC4585033

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.