ArticleFrontiers in behavioral neuroscience2015
Altered activity of the medial prefrontal cortex and amygdala during acquisition and extinction of an active avoidance task.
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The behavioral and neural architecture of observational active avoidance is shaped by demonstrator experience and observer sex.Scientific reports · 2026Article
- Persistent Threat Avoidance Following Negative Reinforcement Is Not Associated with Elevated State Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Behavioral outputs and overlapping circuits between conditional fear and active avoidance.Neurobiology of learning and memory · 2024Review
- The cognitive impact of light: illuminating ipRGC circuit mechanisms.Nature reviews. Neuroscience · 2024Review
- Pathophysiology in cortico-amygdala circuits and excessive aversion processing: the role of oligodendrocytes and myelination.Brain communications · 2024Review
- Distinct Neural Representations and Cognitive Behaviors Attributable to Naturally Developed Active Avoidance or Reactive Escape Strategies in the Male Rat.The international journal of neuropsychopharmacology · 2023Article
- Measuring maladaptive avoidance: from animal models to clinical anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Roadbumps at the Crossroads of Integrating Behavioral andFrontiers in toxicology · 2022Review
- Western Diet Consumption During Development: Setting the Stage for Neurocognitive Dysfunction.Frontiers in neuroscience · 2021Review
- Dopamine modulates individual differences in avoidance behavior: A pharmacological, immunohistochemical, neurochemical and volumetric investigation.Neurobiology of stress · 2020Article
- Know safety, no fear.Neuroscience and biobehavioral reviews · 2020Review
- Partial Predictability in Avoidance Acquisition and Expression of Wistar-Kyoto and Sprague-Dawley Rats: Implications for Anxiety Vulnerability in Uncertain Situations.Frontiers in psychiatry · 2020Article
- The study of active avoidance: A platform for discussion.Neuroscience and biobehavioral reviews · 2019Review
- Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex.eLife · 2018Article
- ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice.Frontiers in molecular neuroscience · 2017Article
- The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm.Molecular psychiatry · 2017Review
- A Window on the Study of Aversive Instrumental Learning: Strains, Performance, Neuroendocrine, and Immunologic Systems.Frontiers in behavioral neuroscience · 2016Article
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5 authors.
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Abstract
Altered medial prefrontal cortex (mPFC) and amygdala function is associated with anxiety-related disorders. While the mPFC-amygdala pathway has a clear role in fear conditioning, these structures are also involved in active avoidance. Given that avoidance perseveration represents a core symptom of anxiety disorders, the neural substrate of avoidance, especially its extinction, requires better understanding. The present study was designed to investigate the activity, particularly, inhibitory neuronal activity in mPFC and amygdala during acquisition and extinction of lever-press avoidance in rats. Neural activity was examined in the mPFC, intercalated cell clusters (ITCs) lateral (LA), basal (BA) and central (CeA) amygdala, at various time points during acquisition and extinction, using induction of the immediate early gene product, c-Fos. Neural activity was greater in the mPFC, LA, BA, and ITC during the extinction phase as compared to the acquisition phase. In contrast, the CeA was the only region that was more activated during acquisition than during extinction. Our results indicate inhibitory neurons are more activated during late phase of acquisition and extinction in the mPFC and LA, suggesting the dynamic involvement of inhibitory circuits in the development and extinction of avoidance response. Together, these data start to identify the key brain regions important in active avoidance behavior, areas that could be associated with avoidance perseveration in anxiety disorders.
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