ArticleFrontiers in neuroanatomy2015
Heterogeneous generation of new cells in the adult echinoderm nervous system.
Article in Frontiers in neuroanatomy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Microbial communities experienced during early development shape the host immune system and epigenome.iScience · 2025Article
- Echinoderm Radial Glia-Like Cells Express Vertebrate Glial Markers.The Journal of comparative neurology · 2025Article
- Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte population.Cell and tissue research · 2023Article
- Echinoderm radial glia in adult cell renewal, indeterminate growth, and regeneration.Frontiers in neural circuits · 2023Review
- The salamander blastema within the broader context of metazoan regeneration.Frontiers in cell and developmental biology · 2023Review
- A subterminal growth zone at arm tip likely underlies life-long indeterminate growth in brittle stars.Frontiers in zoology · 2022Article
- A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Regeneration of the larval sea star nervous system by wounding induced respecification to the Sox2 lineage.eLife · 2022Article
- Radial glia and radial glia-like cells: Their role in neurogenesis and regeneration.Frontiers in neuroscience · 2022Review
- Article
- Coelomocyte replenishment in adult Asterias rubens: the possible ways.Cell and tissue research · 2021Article
- Radial Glia in Echinoderms.Developmental neurobiology · 2019Review
- The complex simplicity of the brittle star nervous system.Frontiers in zoology · 2018Article
- Expression of stem cell factors in the adult sea cucumber digestive tube.Cell and tissue research · 2017Article
- Inhibition of cell proliferation does not slow down echinoderm neural regeneration.Frontiers in zoology · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Adult neurogenesis, generation of new functional cells in the mature central nervous system (CNS), has been documented in a number of diverse organisms, ranging from humans to invertebrates. However, the origin and evolution of this phenomenon is still poorly understood for many of the key phylogenetic groups. Echinoderms are one such phylum, positioned as a sister group to chordates within the monophyletic clade Deuterostomia. They are well known for the ability of their adult organs, including the CNS, to completely regenerate after injury. Nothing is known, however, about production of new cells in the nervous tissue under normal physiological conditions in these animals. In this study, we show that new cells are continuously generated in the mature radial nerve cord (RNC) of the sea cucumber Holothuria glaberrima. Importantly, this neurogenic activity is not evenly distributed, but is significantly more extensive in the lateral regions of the RNC than along the midline. Some of the new cells generated in the apical region of the ectoneural neuroepithelium leave their place of origin and migrate basally to populate the neural parenchyma. Gene expression analysis showed that generation of new cells in the adult sea cucumber CNS is associated with transcriptional activity of genes known to be involved in regulation of various aspects of neurogenesis in other animals. Further analysis of one of those genes, the transcription factor Myc, showed that it is expressed, in some, but not all radial glial cells, suggesting heterogeneity of this CNS progenitor cell population in echinoderms.
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