ArticleFrontiers in cellular neuroscience2015
CD36 is involved in oleic acid detection by the murine olfactory system.
Article in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Olfactory dysfunction in obesity and type 2 diabetes: mechanistic insights from preclinical models.Diabetologia · 2026Review
- Determinants of odorant receptor transcription and gene choice.Chemical senses · 2025Review
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- The role of SNMPs in insect olfaction.Cell and tissue research · 2021Review
- Differential Expression of Mucins in Murine Olfactory Versus Respiratory Epithelium.Chemical senses · 2019Article
- CD 36: Focus on Epigenetic and Post-Transcriptional Regulation.Frontiers in genetics · 2019Review
- Oleic acid stimulates HC11 mammary epithelial cells proliferation and mammary gland development in peripubertal mice through activation of CD36-CaOncotarget · 2018Article
- Access to the odor world: olfactory receptors and their role for signal transduction in insects.Cellular and molecular life sciences : CMLS · 2018Review
- Nutrient Sensing: Another Chemosensitivity of the Olfactory System.Frontiers in physiology · 2017Review
- Taste coding of complex naturalistic taste stimuli and traditional taste stimuli in the parabrachial pons of the awake, freely licking rat.Journal of neurophysiology · 2016Article
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- Lipids and obesity: Also a matter of taste?Reviews in endocrine & metabolic disorders · 2016Review
- CD36 is expressed in a defined subpopulation of neurons in the olfactory epithelium.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory signals influence food intake in a variety of species. To maximize the chances of finding a source of calories, an animal's preference for fatty foods and triglycerides already becomes apparent during olfactory food search behavior. However, the molecular identity of both receptors and ligands mediating olfactory-dependent fatty acid recognition are, so far, undescribed. We here describe that a subset of olfactory sensory neurons expresses the fatty acid receptor CD36 and demonstrate a receptor-like localization of CD36 in olfactory cilia by STED microscopy. CD36-positive olfactory neurons share olfaction-specific transduction elements and project to numerous glomeruli in the ventral olfactory bulb. In accordance with the described roles of CD36 as fatty acid receptor or co-receptor in other sensory systems, the number of olfactory neurons responding to oleic acid, a major milk component, in Ca(2+) imaging experiments is drastically reduced in young CD36 knock-out mice. Strikingly, we also observe marked age-dependent changes in CD36 localization, which is prominently present in the ciliary compartment only during the suckling period. Our results support the involvement of CD36 in fatty acid detection by the mammalian olfactory system.
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