ReviewFrontiers in neuroscience2015
Neuroimaging assessment of early and late neurobiological sequelae of traumatic brain injury: implications for CTE.
Review in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Chronic Traumatic Encephalopathy as the Course of Alzheimer's Disease.International journal of molecular sciences · 2024Article
- Rationale and design of the "NEurodegeneration: Traumatic brain injury as Origin of the Neuropathology (NEwTON)" study: a prospective cohort study of individuals at risk for chronic traumatic encephalopathy.Alzheimer's research & therapy · 2022Observational
- Post-Concussion Syndrome and Chronic Traumatic Encephalopathy: Narrative Review on the Neuropathology, Neuroimaging and Fluid Biomarkers.Diagnostics (Basel, Switzerland) · 2022Review
- Positron emission tomography imaging for the assessment of mild traumatic brain injury and chronic traumatic encephalopathy: recent advances in radiotracers.Neural regeneration research · 2022Article
- Lasting consequences of concussion on the aging brain: Findings from the Baltimore Longitudinal Study of Aging.NeuroImage · 2020Article
- Investigating the cumulative effects of Δ9-tetrahydrocannabinol and repetitive mild traumatic brain injury on adolescent rats.Brain communications · 2020Article
- Recent Preclinical Insights Into the Treatment of Chronic Traumatic Encephalopathy.Frontiers in neuroscience · 2020Review
- [Acta neuropathologica communications · 2019Article
- Every hit matters: White matter diffusivity changes in high school football athletes are correlated with repetitive head acceleration event exposure.NeuroImage. Clinical · 2019Article
- Environmental Subconcussive Injury, Axonal Injury, and Chronic Traumatic Encephalopathy.Frontiers in neurology · 2018Review
- Emotional Lability as a Unique Presenting Sign of Suspected Chronic Traumatic Encephalopathy.Case reports in neurological medicine · 2018Article
- The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases.Journal of neuropathology and experimental neurology · 2018Review
- Trajectory of Parvalbumin Cell Impairment and Loss of Cortical Inhibition in Traumatic Brain Injury.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Frontal Traumatic Brain Injury Increases Impulsive Decision Making in Rats: A Potential Role for the Inflammatory Cytokine Interleukin-12.Journal of neurotrauma · 2017Article
- Fluid biomarkers for mild traumatic brain injury and related conditions.Nature reviews. Neurology · 2016Review
- Blood-Brain Barrier Dysfunction as a Hallmark Pathology in Chronic Traumatic Encephalopathy.Journal of neuropathology and experimental neurology · 2016Article
- The Pathophysiology of Concussion.Current pain and headache reports · 2016Review
- Systems Biology, Neuroimaging, Neuropsychology, Neuroconnectivity and Traumatic Brain Injury.Frontiers in systems neuroscience · 2016Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Traumatic brain injury (TBI) has been increasingly accepted as a major external risk factor for neurodegenerative morbidity and mortality. Recent evidence indicates that the resultant chronic neurobiological sequelae following head trauma may, at least in part, contribute to a pathologically distinct disease known as Chronic Traumatic Encephalopathy (CTE). The clinical manifestation of CTE is variable, but the symptoms of this progressive disease include impaired memory and cognition, affective disorders (i.e., impulsivity, aggression, depression, suicidality, etc.), and diminished motor control. Notably, mounting evidence suggests that the pathology contributing to CTE may be caused by repetitive exposure to subconcussive hits to the head, even in those with no history of a clinically evident head injury. Given the millions of athletes and military personnel with potential exposure to repetitive subconcussive insults and TBI, CTE represents an important public health issue. However, the incidence rates and pathological mechanisms are still largely unknown, primarily due to the fact that there is no in vivo diagnostic tool. The primary objective of this manuscript is to address this limitation and discuss potential neuroimaging modalities that may be capable of diagnosing CTE in vivo through the detection of tau and other known pathological features. Additionally, we will discuss the challenges of TBI research, outline the known pathology of CTE (with an emphasis on Tau), review current neuroimaging modalities to assess the potential routes for in vivo diagnosis, and discuss the future directions of CTE research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.