ArticleRadiological physics and technology2016
Evaluation of X-ray doses and their corresponding biological effects on experimental animals in cone-beam micro-CT scans (R-mCT2).
Article in Radiological physics and technology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Comparing imaging modalities and healing criteria for the estimation of fracture age: a systematic review.International journal of legal medicine · 2026Pooled it
- In vivo micro-computed tomography evaluation of radiopaque, polymeric device degradation in normal and inflammatory environments.Acta biomaterialia · 2024Article
- In vivo Biomedical Imaging of Immune Tolerant, Radiopaque Nanoparticle-Embedded Polymeric Device Degradation.bioRxiv : the preprint server for biology · 2023Article
- In situ sensing physiological properties of biological tissues using wireless miniature soft robots.Science advances · 2023Article
- Ultrahigh resolution whole body photon counting computed tomography as a novel versatile tool for translational research from mouse to man.Zeitschrift fur medizinische Physik · 2023Article
- Radiosafe micro-computed tomography for longitudinal evaluation of murine disease models.Scientific reports · 2019Article
- Preclinical Imaging Biomarkers for Postischaemic Neurovascular Remodelling.Contrast media & molecular imaging · 2019Review
- Standardization of Small Animal Imaging-Current Status and Future Prospects.Molecular imaging and biology · 2018Review
- Technical Note: A benchtop cone-beam x-ray fluorescence computed tomography (XFCT) system with a high-power x-ray source and transmission CT imaging capability.Medical physics · 2018Article
- MÖNCH detector enables fast and low-dose free-propagation phase-contrast computed tomography of in situ mouse lungs.Journal of synchrotron radiation · 2018Article
- Correlation of 360-degree Surface Mapping In Vivo Bioluminescence with Multi-Spectral Optoacoustic Tomography in Human Xenograft Tumor Models.Scientific reports · 2018Article
- Contrast-Enhanced µCT for Visualizing and Evaluating Murine Intestinal Inflammation.Theranostics · 2018Article
- X-ray luminescence computed tomography using a focused x-ray beam.Journal of biomedical optics · 2017Article
- Dosimetry in Micro-computed Tomography: a Review of the Measurement Methods, Impacts, and Characterization of the Quantum GX Imaging System.Molecular imaging and biology · 2017Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies show that the radiation dose received during a micro-CT examination may have adverse effects on living subjects. However, the correlations between the biological effects and the radiation doses have never been thoroughly evaluated in the majority of cases. In this study, we evaluated the biological radiation effects of measured radiation doses in ICR mice using cone-beam micro-CT scans. Long-term in vivo whole-body micro-CT scans of ICR mice were performed for a duration of 4 weeks. Although a scanning frequency of three scans per week is higher than that necessary for conventional studies, this study represents particular cases where the subjects may undergo an extreme number of examinations. The average X-ray dose of a CT scan measures 16.19 mGy at the center of a phantom and 16.24 mGy at an offset position of 7.5 mm from the center of the phantom. The total average dose at the center of the phantom during the 4-week scanning period was 194.3 mGy. No significant radiation effects were observed in the weight gain curves, organ weights, blood analyses, litter sizes, reared offspring sizes, and the histopathologic results. Therefore, it is unlikely that the measured doses for the CT scans caused any radiation damage in the mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.