ArticleHuman brain mapping2016
Spatial patterns of atrophy, hypometabolism, and amyloid deposition in Alzheimer's disease correspond to dissociable functional brain networks.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
90 citing papers in PubMed, 3 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Cognitive and Neuropathophysiological Outcomes of Gamma-tACS in Dementia: A Systematic Review.Neuropsychology review · 2024Pooled it
- The Amyloid-β Pathway in Alzheimer's Disease.Molecular psychiatry · 2021Pooled it
- Processing speed and attention training modifies autonomic flexibility: A mechanistic intervention study.NeuroImage · 2020Trial
- Widespread synaptic density loss in schizophrenia follows molecular and network architecture.Molecular psychiatry · 2026Article
- Mapping individual molecular connectomes in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Integrating anatomical priors and clinical semantics for MRI-based diagnosis and care support in Alzheimer's disease.Frontiers in neuroscience · 2026Article
- Morphological variations and cortical atrophy of the precuneus in normal aging and Alzheimer's disease.Journal of anatomy · 2026Article
- Anterior temporal lobe, word comprehension, and physiology of atrophy in semantic primary progressive aphasia.Neurocase · 2025Article
- Modeling Alzheimer's disease: Bayesian copula graphical model from demographic, cognitive, and neuroimaging data.Journal of Alzheimer's disease : JAD · 2025Article
- Regional Brain Metabolism across the Alzheimer's Disease Continuum in Down Syndrome.Annals of neurology · 2025Article
- Cortical hypometabolism in Parkinson's disease is linked to cholinergic basal forebrain atrophy.Molecular psychiatry · 2025Article
- Data-driven characterization of distinct cognitive subtypes in Parkinson's disease dementia.NPJ Parkinson's disease · 2025Article
- Neuromark PET: A multivariate method for estimating whole brain fMRI guided intrinsic networks and connectomes from fMRI and PET data.bioRxiv : the preprint server for biology · 2025Article
- Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease.Brain communications · 2025Article
- Sex-specific topological structure associated with dementia via latent space estimation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Story recall performance and AT classification via positron emission tomography: A comparison of logical memory and Craft Story 21.Journal of the neurological sciences · 2024Article
- The characteristic patterns of individual brain susceptibility networks underlie Alzheimer's disease and white matter hyperintensity-related cognitive impairment.Translational psychiatry · 2024Article
- Topographic metabolism-function relationships in Alzheimer's disease: A simultaneous PET/MRI study.Human brain mapping · 2024Article
- Divergent neurodegenerative patterns: Comparison of [Brain communications · 2024Article
30 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent neuroimaging studies of Alzheimer's disease (AD) have emphasized topographical similarities between AD-related brain changes and a prominent cortical association network called the default-mode network (DMN). However, the specificity of distinct imaging abnormalities for the DMN compared to other intrinsic connectivity networks (ICNs) of the limbic and heteromodal association cortex has not yet been examined systematically. We assessed regional amyloid load using AV45-PET, neuronal metabolism using FDG-PET, and gray matter volume using structural MRI in 473 participants from the Alzheimer's Disease Neuroimaging Initiative, including preclinical, predementia, and clinically manifest AD stages. Complementary region-of-interest and voxel-based analyses were used to assess disease stage- and modality-specific changes within seven principle ICNs of the human brain as defined by a standardized functional connectivity atlas. Amyloid deposition in AD dementia showed a preference for the DMN, but high effect sizes were also observed for other neocortical ICNs, most notably the frontoparietal-control network. Atrophic changes were most specific for an anterior limbic network, followed by the DMN, whereas other neocortical networks were relatively spared. Hypometabolism appeared to be a mixture of both amyloid- and atrophy-related profiles. Similar patterns of modality-dependent network specificity were also observed in the predementia and, for amyloid deposition, in the preclinical stage. These quantitative data confirm a high vulnerability of the DMN for multimodal imaging abnormalities in AD. However, rather than being selective for the DMN, imaging abnormalities more generally affect higher order cognitive networks and, importantly, the vulnerability profiles of these networks markedly differ for distinct aspects of AD pathology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.