ArticleCell stress & chaperones2016
Hospitalized dogs recovery from naturally occurring heatstroke; does serum heat shock protein 72 can provide prognostic biomarker?
Article in Cell stress & chaperones, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- The Influence of Environmental and Genetic Factors and Training Background on the Welfare of Herding Dogs.Animals : an open access journal from MDPI · 2026Review
- Impact of hyper- and hypothermia on cellular and whole-body physiology.Journal of intensive care · 2025Review
- The pathogenesis and therapeutic strategies of heat stroke-induced endothelial injury.Frontiers in cell and developmental biology · 2025Review
- Biomarkers of heatstroke-induced organ injury and repair.Experimental physiology · 2022Review
- Heat stroke in dogs: Literature review.Veterinarni medicina · 2022Review
- A mouse model of exertional heatstroke-related acute kidney injury.Annals of translational medicine · 2022Article
- The impact of castration on physiological responses to exertional heat stroke in mice.PloS one · 2022Article
- Dogs Don't Die Just in Hot Cars-Exertional Heat-Related Illness (Heatstroke) Is a Greater Threat to UK Dogs.Animals : an open access journal from MDPI · 2020Article
- Impacts of previous heatstroke history on physiological parameters eHSP72 and biomarkers of oxidative stress in military working dogs.Cell stress & chaperones · 2019Article
- Serum histones as biomarkers of the severity of heatstroke in dogs.Cell stress & chaperones · 2017Article
- Pathophysiology of heatstroke in dogs - revisited.Temperature (Austin, Tex.) · 2017Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heatstroke is a serious illness in dogs characterized by core temperatures above 41°C with central nervous system dysfunction. Experimental heatstroke models have tried to correlate biomarker levels with the severity of the syndrome. Serum heat shock protein (eHSP70) levels were recently evaluated as a biomarker of heat tolerance and acclimation, their role as a marker of heatstroke is inconclusive. Here, we monitored eHSP70 levels in correlation with systemic biomarkers in 30 naturally occurring canine heatstroke cases. Thirty dogs diagnosed with environmental (33%) or exertional (66%) heatstroke admitted to hospital (0-14 h post-injury) were tested for biomarkers of organ damage and coagulation parameters. eHSP70 levels were measured upon admission and 4, 12, and 24 h later (T1, T2, and T3, respectively). No differences were found between exertional and environmental heatstroke cases. The eHSP profile demonstrated an inverted bell shape, with the lowest levels at the 12 h time point. A positive correlation between eHSP70, lactate, and aPPT was also noted at T2 in all the dogs in the study. Twenty-four h after presentation, eHSP70 levels returned to those measured upon admission, this change was only significant in the survivors. The obtained results suggest that eHSP72 level profile may be predictive of survival.
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