ArticleThe American journal of psychiatry2016
Gating Deficit Heritability and Correlation With Increased Clinical Severity in Schizophrenia Patients With Positive Family History.
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Article in The American journal of psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18citing papers in PubMed, 1 pooled it
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Genetic Determinants of Gating Functions: Do We Get Closer to Understanding Schizophrenia Etiopathogenesis?Frontiers in psychiatry · 2020Pooled it
- Article
- Prospective longitudinal assessment of sensorimotor gating as a risk/resiliency factor for posttraumatic stress disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition.Brain sciences · 2022Article
- [Twelve years of research domain criteria in psychiatric research and practice: claim and reality].Der Nervenarzt · 2021Review
- Prepulse Inhibition in Cocaine Addiction and Dual Pathologies.Brain sciences · 2021Article
- Professor Robert Freedman and his contributions to psychiatric research.Pediatric investigation · 2020Article
- Neuroendocrine, epigenetic, and intergenerational effects of general anesthetics.World journal of psychiatry · 2020Review
- P50 inhibitory sensory gating in schizophrenia: analysis of recent studies.Schizophrenia research · 2020Article
- PsyCoP - A Platform for Systematic Semi-Automated Behavioral and Cognitive Profiling Reveals Gene and Environment Dependent Impairments of Tcf4 Transgenic Mice Subjected to Social Defeat.Frontiers in behavioral neuroscience · 2020Article
- Endophenotypes in Schizophrenia: Digging Deeper to Identify Genetic Mechanisms.Journal of psychiatry and brain science · 2019Article
- Abnormal Entropy Modulation of the EEG Signal in Patients With Schizophrenia During the Auditory Paired-Stimulus Paradigm.Frontiers in neuroinformatics · 2019Article
- Aberrant Middle Prefrontal-Motor Cortex Connectivity Mediates Motor Inhibitory Biomarker in Schizophrenia.Biological psychiatry · 2019Article
- Neurobiological Determinants of Tobacco Smoking in Schizophrenia.Frontiers in psychiatry · 2018Review
- Impact of Familial Loading on Prefrontal Activation in Major Psychiatric Disorders: A Near-Infrared Spectroscopy (NIRS) Study.Scientific reports · 2017Article
- New paradigm for auditory paired pulse suppression.PloS one · 2017Article
- Practice and Learning: Spatiotemporal Differences in Thalamo-Cortical-Cerebellar Networks Engagement across Learning Phases in Schizophrenia.Frontiers in psychiatry · 2016Article
- Reduced Prepulse Inhibition as a Biomarker of Schizophrenia.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
21 authors at 1 institution in 1 country.
Tiffany A GreenwoodFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Gregory A LightFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Neal R SwerdlowFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Monica E CalkinsFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Michael F GreenFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Raquel E GurFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Ruben C GurFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Laura C LazzeroniFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Keith H NuechterleinFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Ann OlincyFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Allen D RadantFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Larry J SeidmanFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Larry J SieverFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Jeremy M SilvermanFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
William S StoneFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Catherine A SugarFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Debby W TsuangFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Ming T TsuangFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Bruce I TuretskyFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
Robert FreedmanFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
David L BraffFrom the Department of Psychiatry, the Center for Behavioral Genomics, and the Institute for Genomic Medicine, UC San Diego, La Jolla, Calif.; VISN 22 Mental Illness Research, Education and Clinical Center, VA San Diego Healthcare System, San Diego; the Department of Psychiatry, University of Pennsylvania, Philadelphia; the Department of Psychiatry and Biobehavioral Sciences, UCLA, the Department of Biostatistics, School of Public Health, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles; the Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif.; the Department of Psychiatry, University of Colorado Health Sciences Center, Denver; the Department of Psychiatry and Behavioral Sciences, University of Washington, and VA Puget Sound Health Care System, Seattle; the Department of Psychiatry, Harvard Medical School, the Harvard Institute of Psychiatric Epidemiology and Genetics, and the Division of Public Psychiatry, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Boston; the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, and the James J. Peters VA Medical Center, New York.
VA San Diego Healthcare System · US
Funding
The Genetics of Endophenotypes and SchizophreniaR01MH065571 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRAFF, DAVID L. · 2003 to 2013
$7.0MThe Genetics of Endophenotypes and SchizophreniaR01MH065578 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2003 to 2013
$4.2MThe Genetics of Endophenotypes and SchizophreniaR01MH065554 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SIEVER, LARRY J · 2003 to 2013
$4.1MGenetics of Endophenotypes and SchizophreniaR01MH065558 · NIMH · UNIVERSITY OF WASHINGTON · PI TSUANG, DEBBY WEN · 2003 to 2013
$3.7MThe Genetics of Endophenotypes and SchizophreniaR01MH065707 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, MICHAEL F. · 2003 to 2013
$3.6MThe Genetics of Endophenotypes and SchizophreniaR01MH065562 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SEIDMAN, LARRY J · 2003 to 2007
$2.6MThe Genetics of Endophenotypes and SchizophreniaR01MH065588 · NIMH · UNIVERSITY OF COLORADO DENVER · PI OLINCY, ANN · 2003 to 2007
$2.2M6/6 - The Genetics of Endophenotypes and SchizophreniaR01MH086135 · NIMH · STANFORD UNIVERSITY · PI LAZZERONI, LAURA C. · 2010 to 2013
$1.3MThe Convergence and Divergence of Schizophrenia and Bipolar DisorderK01MH087889 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GREENWOOD, TIFFANY A · 2010 to 2014
$858kDeep Sequencing in SchizophreniaI01BX002241 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI TSUANG, DEBBY WEN · 2014 to 2017
–BLRD VA I01 BX002241NIMH NIH HHS K01 MH087889NIMH NIH HHS K01-MH087889NIMH NIH HHS R01 MH065554NIMH NIH HHS R01-MH065554NIMH NIH HHS R01 MH065558NIMH NIH HHS R01-MH065558NIMH NIH HHS R01 MH065562NIMH NIH HHS R01-MH065562NIMH NIH HHS R01 MH065571NIMH NIH HHS R01-MH065571NIMH NIH HHS R01 MH065578NIMH NIH HHS R01-MH065578NIMH NIH HHS R01 MH065588NIMH NIH HHS R01-MH065588NIMH NIH HHS R01 MH065707NIMH NIH HHS R01-MH065707NIMH NIH HHS R01 MH086135NIMH NIH HHS R01 MH86135
Abstract
objectiveThe Consortium on the Genetics of Schizophrenia Family Study evaluated 12 primary and other supplementary neurocognitive and neurophysiological endophenotypes in schizophrenia probands and their families. Previous analyses of prepulse inhibition (PPI) and P50 gating measures in this sample revealed heritability estimates that were lower than expected based on earlier family studies. Here the authors investigated whether gating measures were more heritable in multiply affected families with a positive family history compared with families with only a single affected proband (singleton).
methodA total of 296 nuclear families consisting of a schizophrenia proband, at least one unaffected sibling, and both parents underwent a comprehensive endophenotype and clinical characterization. The Family Interview for Genetic Studies was administered to all participants and used to obtain convergent psychiatric symptom information for additional first-degree relatives. Among the families, 97 were multiply affected, and 96 were singletons.
resultsBoth PPI and P50 gating displayed substantially increased heritability in the 97 multiply affected families (47% and 36%, respectively) compared with estimates derived from the entire sample of 296 families (29% and 20%, respectively). However, no evidence for heritability was observed for either measure in the 96 singleton families. Schizophrenia probands derived from the multiply affected families also displayed a significantly increased severity of clinical symptoms compared with those from singleton families.
conclusionsPPI and P50 gating measures demonstrate substantially increased heritability in schizophrenia families with a higher genetic vulnerability for illness, providing further support for the commonality of genes underlying both schizophrenia and gating measures.
Indexed as
EndophenotypesFamilySchizophrenic PsychologyAdolescentAdultAgedBrainElectroencephalographyEvoked PotentialsFemaleHumansMaleMiddle AgedParentsPrepulse InhibitionSchizophrenia
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