Evidence map›Paper›PMID 26441155›Full record

Trial reportThe American journal of psychiatry2016

Neural Correlates of the Propensity for Retaliatory Behavior in Youths With Disruptive Behavior Disorders.

Stuart F White, Michelle VanTieghem, Sarah J Brislin, Isaiah Sypher, Stephen Sinclair, Daniel S Pine, Soonjo Hwang, R James R Blair

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.

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  19. Traits of empathy and anger: implications for psychopathy and other disorders associated with aggression.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Stuart F WhiteFrom the Section on Affective Cognitive Neuroscience and the Section on Development and Affective Neuroscience, NIMH, Bethesda, Md.; the Department of Psychology, Columbia University, New York; and the Department of Psychology, Florida State University, Tallahassee.
Michelle VanTieghemFrom the Section on Affective Cognitive Neuroscience and the Section on Development and Affective Neuroscience, NIMH, Bethesda, Md.; the Department of Psychology, Columbia University, New York; and the Department of Psychology, Florida State University, Tallahassee.
Sarah J BrislinFrom the Section on Affective Cognitive Neuroscience and the Section on Development and Affective Neuroscience, NIMH, Bethesda, Md.; the Department of Psychology, Columbia University, New York; and the Department of Psychology, Florida State University, Tallahassee.
Isaiah SypherFrom the Section on Affective Cognitive Neuroscience and the Section on Development and Affective Neuroscience, NIMH, Bethesda, Md.; the Department of Psychology, Columbia University, New York; and the Department of Psychology, Florida State University, Tallahassee.
Stephen SinclairFrom the Section on Affective Cognitive Neuroscience and the Section on Development and Affective Neuroscience, NIMH, Bethesda, Md.; the Department of Psychology, Columbia University, New York; and the Department of Psychology, Florida State University, Tallahassee.
Daniel S PineFrom the Section on Affective Cognitive Neuroscience and the Section on Development and Affective Neuroscience, NIMH, Bethesda, Md.; the Department of Psychology, Columbia University, New York; and the Department of Psychology, Florida State University, Tallahassee.
Soonjo HwangFrom the Section on Affective Cognitive Neuroscience and the Section on Development and Affective Neuroscience, NIMH, Bethesda, Md.; the Department of Psychology, Columbia University, New York; and the Department of Psychology, Florida State University, Tallahassee.
R James R BlairFrom the Section on Affective Cognitive Neuroscience and the Section on Development and Affective Neuroscience, NIMH, Bethesda, Md.; the Department of Psychology, Columbia University, New York; and the Department of Psychology, Florida State University, Tallahassee.
Institut des Sciences Cognitives Marc Jeannerod · FR

Funding

Fmri Studies Of Risk For Mood And Anxiety Disorders In ChildrenZIAMH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$28.3M
Emotional Dysfunction and Childhood Behavioral DisturbanceZIAMH002860 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BLAIR, JAMES R · 2009 to 2016
$9.5M
Emotional dysfunction--childhood behavioral disturbanceZ01MH002860 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BLAIR, JAMES · 2005 to 2008
$2.0M
fMRI Study Of Risk Of Mood/Anxiety Disorders In ChildrenZ01MH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2002 to 2008
$1.7M
Acute threat and frustrative non-reward components of irritability and reactive aggressionK22MH109558 · NIMH · FATHER FLANAGAN'S BOYS' HOME · PI BLAIR, JAMES · 2016 to 2018
$972k
Intramural NIH HHS Z01 MH002782Intramural NIH HHS Z01 MH002860Intramural NIH HHS ZIA MH002782Intramural NIH HHS ZIA MH002860NIMH NIH HHS 1-ZIA-MH002782NIMH NIH HHS 1-ZIA-MH002860NIMH NIH HHS K22 MH109558
6 · The paper itself

Abstract

objectiveYouths with disruptive behavior disorders (DBD) (conduct disorder and oppositional defiant disorder) have an elevated risk for maladaptive reactive aggression. Theory suggests that this is due to an elevated sensitivity of basic threat circuitry implicated in retaliation (amygdala/periaqueductal gray) in youths with DBD and low levels of callous-unemotional traits and dysfunctional regulatory activity in the ventromedial prefrontal cortex in youths with DBD irrespective of callous-unemotional traits.

methodA total of 56 youths 10-18 years of age (23 of them female) participated in the study: 30 youths with DBD, divided by median split into groups with high and low levels of callous-unemotional traits, and 26 healthy youths. All participants completed an ultimatum game task during functional MRI.

resultsRelative to the other groups, youths with DBD and low levels of callous-unemotional traits showed greater increases in activation of basic threat circuitry when punishing others and dysfunctional down-regulation of the ventromedial prefrontal cortex during retaliation. Relative to healthy youths, all youths with DBD showed reduced amygdala-ventromedial prefrontal cortex connectivity during high provocation. Ventromedial prefrontal cortex responsiveness and ventromedial prefrontal cortex-amygdala connectivity were related to patients' retaliatory propensity (behavioral responses during the task) and parent-reported reactive aggression.

conclusionsThese data suggest differences in the underlying neurobiology of maladaptive reactive aggression in youths with DBD who have relatively low levels of callous-unemotional traits. Youths with DBD and low callous-unemotional traits alone showed significantly greater threat responses during retaliation relative to comparison subjects. These data also suggest that ventromedial prefrontal cortex-amygdala connectivity is critical for regulating retaliation/reactive aggression and, when dysfunctional, contributes to reactive aggression, independent of level of callous-unemotional traits.

Indexed as

Attention Deficit and Disruptive Behavior DisordersAdolescentAggressionAmygdalaChildChild BehaviorEmotionsFemaleHumansMagnetic Resonance ImagingMaleOutcome Assessment, Health CarePrefrontal CortexProblem BehaviorPsychiatric Status Rating ScalesTask Performance and Analysis

Identifiers

PMID26441155
PMCPMC4950844
OpenAlexW1865151196

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.