ArticleNature reviews. Clinical oncology2015
Clinical trials: Early phase clinical trials-are dose expansion cohorts needed?
Article in Nature reviews. Clinical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Expansion cohorts in phase 1 oncology trials: a systematic review of their design, implementation and outcomes.British journal of cancer · 2026Pooled it
- Evaluating the role of phase I expansion cohorts in oncologic drug development.Investigational new drugs · 2017Pooled it
- Using Dose-Escalation and -Expansion Cohort Study as Pivotal Trial for Targeted Anticancer Drug Approval.JCO precision oncology · 2025Review
- Reporting quality of dose-expansion cohorts in trials of anticancer drugs could be improved: a cross-sectional study.Trials · 2025Article
- Seamless trials in oncology: A cross-sectional analysis of characteristics and reporting.PloS one · 2024Article
- Controlled amplification in oncology dose-finding trials.Contemporary clinical trials · 2023Article
- Stopping rules for phase I clinical trials with dose expansion cohorts.Statistical methods in medical research · 2022Article
- Radiation therapy: An old dog learning new tricks.Methods in cell biology · 2022Article
- Characteristics of Early Phase Clinical Trials for Rare Cancers: Insights From Interviews With Stakeholders.Frontiers in pharmacology · 2022Article
- A latent variable model for improving inference in trials assessing the effect of dose on toxicity and composite efficacy endpoints.Statistical methods in medical research · 2020Article
- The Impact of Early-Phase Trial Design in the Drug Development Process.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Article
- Design considerations for early-phase clinical trials of immune-oncology agents.Journal for immunotherapy of cancer · 2018Article
- Overcoming obstacles in the design of cancer anorexia/weight loss trials.Critical reviews in oncology/hematology · 2017Review
- Use of Expansion Cohorts in Phase I Trials and Probability of Success in Phase II for 381 Anticancer Drugs.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
- Statistical controversies in clinical research: building the bridge to phase II-efficacy estimation in dose-expansion cohorts.Annals of oncology : official journal of the European Society for Medical Oncology · 2017Article
- Sequential monitoring of Phase I dose expansion cohorts.Statistics in medicine · 2017Article
- An analysis of common ethical justifications for compassionate use programs for experimental drugs.BMC medical ethics · 2016Article
- Integrating the escalation and dose expansion studies into a unified Phase I clinical trial.Contemporary clinical trials · 2016Article
- The European Organization for Research and Treatment of Cancer perspective on designing clinical trials with immune therapeutics.Annals of translational medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.