ArticleHuman brain mapping2015
Regional volumes in brain stem and cerebellum are associated with postural impairments in young brain-injured patients.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of dual-task training on chronic ankle instability: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2023Pooled it
- Effect of cognitive task complexity on dual task postural stability: a systematic review and meta-analysis.Experimental brain research · 2022Pooled it
- A systematic review of cross-sectional differences and longitudinal changes to the morphometry of the brain following paediatric traumatic brain injury.NeuroImage. Clinical · 2019Pooled it
- Structural brain correlates of balance control in children with cerebral palsy: baseline correlations and effects of training.Brain structure & function · 2025Trial
- Brain Magnetic Resonance Imaging Volumetric Measures of Functional Outcome after Severe Traumatic Brain Injury in Adolescents.Journal of neurotrauma · 2021Trial
- Postural control in children with spastic cerebral palsy: the role of brain lesion characteristics.Pediatric research · 2026Article
- Cerebellar Electrical Activity as a Marker for Predicting Brain Health and Disease: A Review.Brain sciences · 2026Review
- Pontine pathology mediates common symptoms of blast-induced chronic mild traumatic brain injury.Brain communications · 2026Article
- Exploring the Therapeutic Effects and Mechanisms of Transcranial Alternating Current Stimulation on Improving Walking Ability in Stroke Patients via Modulating Cerebellar Gamma Frequency Band-a Narrative Review.Cerebellum (London, England) · 2024Review
- Article
- Disrupted topological organization of functional brain networks in traumatic axonal injury.Brain imaging and behavior · 2024Article
- Consensus Paper: Ataxic Gait.Cerebellum (London, England) · 2023Article
- Pattern of cerebellar grey matter loss associated with ataxia severity in spinocerebellar ataxias type 3: a multi-voxel pattern analysis.Brain imaging and behavior · 2022Article
- Cerebellar and brainstem differences in children with developmental coordination disorder: A voxel-based morphometry study.Frontiers in human neuroscience · 2022Article
- Dynamic Visual Stimulations Produced in a Controlled Virtual Reality Environment Reveals Long-Lasting Postural Deficits in Children With Mild Traumatic Brain Injury.Frontiers in neurology · 2021Article
- Balance and the brain: A review of structural brain correlates of postural balance and balance training in humans.Gait & posture · 2019Review
- Physical Performance and Fall Risk in Persons With Traumatic Brain Injury.Perceptual and motor skills · 2019Article
- Weight loss, behavioral change, and structural neuroplasticity in children with obesity through a multidisciplinary treatment program.Human brain mapping · 2019Article
- Enhanced prefrontal functional-structural networks to support postural control deficits after traumatic brain injury in a pediatric population.Network neuroscience (Cambridge, Mass.) · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many patients with traumatic brain injury (TBI) suffer from postural control impairments that can profoundly affect daily life. The cerebellum and brain stem are crucial for the neural control of posture and have been shown to be vulnerable to primary and secondary structural consequences of TBI. The aim of this study was to investigate whether morphometric differences in the brain stem and cerebellum can account for impairments in static and dynamic postural control in TBI. TBI patients (n = 18) and healthy controls (n = 30) completed three challenging postural control tasks on the EquiTest® system (Neurocom). Infratentorial grey matter (GM) and white matter (WM) volumes were analyzed with cerebellum-optimized voxel-based morphometry using the spatially unbiased infratentorial toolbox. Volume loss in TBI patients was revealed in global cerebellar GM, global infratentorial WM, middle cerebellar peduncles, pons and midbrain. In the TBI group and across both groups, lower postural control performance was associated with reduced GM volume in the vermal/paravermal regions of lobules I-IV, V and VI. Moreover, across all participants, worse postural control performance was associated with lower WM volume in the pons, medulla, midbrain, superior and middle cerebellar peduncles and cerebellum. This is the first study in TBI patients to demonstrate an association between postural impairments and reduced volume in specific infratentorial brain areas. Volumetric measures of the brain stem and cerebellum may be valuable prognostic markers of the chronic neural pathology, which complicates rehabilitation of postural control in TBI.
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