ArticlePloS one2015
A Gamma-Knife-Enabled Mouse Model of Cerebral Single-Hemisphere Delayed Radiation Necrosis.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- A mouse model of stereotactic radiosurgery-induced neuroinflammation and blood-brain barrier compromise.Acta neuropathologica communications · 2025Article
- Preclinical dose assessment of cyberknife with small animal intracranial irradiation using a 3D printed mouse phantom.Scientific reports · 2025Article
- Deuterium Magnetic Resonance Spectroscopy Quantifies Tumor Fraction in a Mouse Model of a Mixed Radiation Necrosis / GL261-Glioblastoma Lesion.Molecular imaging and biology · 2024Article
- Presence of Activated (Phosphorylated) STAT3 in Radiation Necrosis Following Stereotactic Radiosurgery for Brain Metastases.International journal of molecular sciences · 2023Article
- Distinguishing Tumor Admixed in a Radiation Necrosis (RN) Background:Frontiers in oncology · 2022Article
- Preservation of neurocognitive function in the treatment of brain metastases.Neuro-oncology advances · 2021Article
- Establishment and Validation of CyberKnife Irradiation in a Syngeneic Glioblastoma Mouse Model.Cancers · 2021Article
- Irradiation-Modulated Murine Brain Microenvironment Enhances GL261-Tumor Growth and Inhibits Anti-PD-L1 Immunotherapy.Frontiers in oncology · 2021Article
- Can a comparison of clinical and deep space irradiation scenarios shed light on the radiation response of the brain?The British journal of radiology · 2020Article
- Late Side Effects in Normal Mouse Brain Tissue After Proton Irradiation.Frontiers in oncology · 2020Article
- Minimal difference between fractionated and single-fraction exposure in a murine model of radiation necrosis.Radiation oncology (London, England) · 2019Article
- Late Effects of Radiation Prime the Brain Microenvironment for Accelerated Tumor Growth.International journal of radiation oncology, biology, physics · 2019Article
- UHRF1 suppression promotes cell differentiation and reduces inflammatory reaction in anaplastic thyroid cancer.Oncotarget · 2018Article
- Label-free fluorescence lifetime spectroscopy detects radiation-induced necrotic changes in live brain in real-time.Biomedical optics express · 2018Article
- Discriminating radiation injury from recurrent tumor with [EJNMMI research · 2018Article
- Preclinical MRI: Studies of the irradiated brain.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
- Inhibitors of HIF-1α and CXCR4 Mitigate the Development of Radiation Necrosis in Mouse Brain.International journal of radiation oncology, biology, physics · 2018Article
- The effect of radiation dose on the onset and progression of radiation-induced brain necrosis in the rat model.International journal of radiation biology · 2017Article
- Can anti-vascular endothelial growth factor antibody reverse radiation necrosis? A preclinical investigation.Journal of neuro-oncology · 2017Article
- Development and Validation of a Small Animal Immobilizer and Positioning System for the Study of Delivery of Intracranial and Extracranial Radiotherapy Using the Gamma Knife System.Technology in cancer research & treatment · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo develop a Gamma Knife-based mouse model of late time-to-onset, cerebral radiation necrosis (RN) with serial evaluation by magnetic resonance imaging (MRI) and histology. METHODS AND MATERIALS: Mice were irradiated with the Leksell Gamma Knife® (GK) PerfexionTM (Elekta AB; Stockholm, Sweden) with total single-hemispheric radiation doses (TRD) of 45- to 60-Gy, delivered in one to three fractions. RN was measured using T2-weighted MR images, while confirmation of tissue damage was assessed histologically by hematoxylin & eosin, trichrome, and PTAH staining.
resultsMRI measurements demonstrate that TRD is a more important determinant of both time-to-onset and progression of RN than fractionation. The development of RN is significantly slower in mice irradiated with 45-Gy than 50- or 60-Gy, where RN development is similar. Irradiated mouse brains demonstrate all of the pathologic features observed clinically in patients with confirmed RN. A semi-quantitative (0 to 3) histologic grading system, capturing both the extent and severity of injury, is described and illustrated. Tissue damage, as assessed by a histologic score, correlates well with total necrotic volume measured by MRI (correlation coefficient = 0.948, with p<0.0001), and with post-irradiation time (correlation coefficient = 0.508, with p<0.0001).
conclusionsFollowing GK irradiation, mice develop late time-to-onset cerebral RN histology mirroring clinical observations. MR imaging provides reliable quantification of the necrotic volume that correlates well with histologic score. This mouse model of RN will provide a platform for mechanism of action studies, the identification of imaging biomarkers of RN, and the development of clinical studies for improved mitigation and neuroprotection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.