Evidence map›Paper›PMID 26440760›Full record

ArticleJournal of biomedical optics2015

Augmented microscopy: real-time overlay of bright-field and near-infrared fluorescence images.

Jeffrey R Watson, Christian F Gainer, Nikolay Martirosyan, Jesse Skoch, G Michael Lemole, Rein Anton, Marek Romanowski

Abstract readEvaluation Study
In one paragraph

Article in Journal of biomedical optics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  3. Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeffrey R WatsonUniversity of Arizona, Department of Biomedical Engineering, 1657 E. Helen Street, Tucson, Arizona 85721, United States.
Christian F GainerUniversity of Arizona, Department of Biomedical Engineering, 1657 E. Helen Street, Tucson, Arizona 85721, United States.
Nikolay MartirosyanUniversity of Arizona, Division of Neurosurgery, Department of Surgery, 1501 N. Campbell Avenue, Tucson, Arizona 85721, United States.
Jesse SkochUniversity of Arizona, Division of Neurosurgery, Department of Surgery, 1501 N. Campbell Avenue, Tucson, Arizona 85721, United States.
G Michael LemoleUniversity of Arizona, Division of Neurosurgery, Department of Surgery, 1501 N. Campbell Avenue, Tucson, Arizona 85721, United States.
Rein AntonUniversity of Arizona, Division of Neurosurgery, Department of Surgery, 1501 N. Campbell Avenue, Tucson, Arizona 85721, United States.
Marek RomanowskiUniversity of Arizona, Department of Biomedical Engineering, 1657 E. Helen Street, Tucson, Arizona 85721, United States.

Funding

Cardiovascular Biomedical Engineering Training GrantT32HL007955 · NHLBI · UNIVERSITY OF ARIZONA · PI BARTON, JENNIFER KEHLET · 2001 to 2020
$5.1M
A near-infrared contrast agent for targeted imaging of cancerK25CA120350 · NCI · UNIVERSITY OF ARIZONA · PI ROMANOWSKI, MAREK J · 2007 to 2011
$798k
NCI NIH HHS CA120350NHLBI NIH HHS HL007955NHLBI NIH HHS T32 HL007955
6 · The paper itself

Abstract

Intraoperative applications of near-infrared (NIR) fluorescent contrast agents can be aided by instrumentation capable of merging the view of surgical field with that of NIR fluorescence. We demonstrate augmented microscopy, an intraoperative imaging technique in which bright-field (real) and electronically processed NIR fluorescence (synthetic) images are merged within the optical path of a stereomicroscope. Under luminance of 100,000 lx, representing typical illumination of the surgical field, the augmented microscope detects 189 nM concentration of indocyanine green and produces a composite of the real and synthetic images within the eyepiece of the microscope at 20 fps. Augmentation described here can be implemented as an add-on module to visualize NIR contrast agents, laser beams, or various types of electronic data within the surgical microscopes commonly used in neurosurgical, cerebrovascular, otolaryngological, and ophthalmic procedures.

Indexed as

Fluorescent DyesComputer SystemsEquipment DesignEquipment Failure AnalysisImage EnhancementInfrared RaysMicroscopy, FluorescenceMicrosurgeryReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueSurgery, Computer-AssistedFluorescent Dyes

Identifiers

PMID26440760
PMCPMC4881285

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.