Evidence map›Paper›PMID 26440741›Full record

ArticleLeukemia & lymphoma2016

Preclinical combination of TP-0903, an AXL inhibitor and B-PAC-1, a procaspase-activating compound with ibrutinib in chronic lymphocytic leukemia.

Viralkumar Patel, Michael J Keating, William G Wierda, Varsha Gandhi

Open access · greenAbstract readLetter
In one paragraph

Article in Leukemia & lymphoma, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
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  5. Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer.International journal of molecular sciences · 2021
    Review
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  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Viralkumar Patela Department of Experimental Therapeutics , The University of Texas MD Anderson Cancer Center , Houston , TX , USA ;
Michael J Keatingb Department of Leukemia , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
William G Wierdab Department of Leukemia , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
Varsha Gandhia Department of Experimental Therapeutics , The University of Texas MD Anderson Cancer Center , Houston , TX , USA ;
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Tissue CoreP01CA081534 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KIPPS, THOMAS J · 2000 to 2016
$59.5M
NCI NIH HHS P01 CA081534NCI NIH HHS P01CA81534NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdenineAntineoplastic AgentsAxl Receptor Tyrosine KinaseBenzenesulfonamidesCaspasesDose-Response Relationship, DrugDrug Evaluation, PreclinicalDrug Therapy, CombinationHumansHydrazonesInhibitory Concentration 50Leukemia, Lymphocytic, Chronic, B-CellPiperazinesPiperidinesProto-Oncogene ProteinsPyrazoles2-(4-(4-(benzyloxy)benzyl)piperazin-1-yl)-N'-(3,5-di-tert-butyl-2-hydroxybenzylidene)acetohydrazideAdenineAntineoplastic AgentsAXL protein, humanAxl Receptor Tyrosine KinaseBenzenesulfonamidesCaspasesdubermatinibHydrazonesibrutinibPiperazinesPiperidinesProto-Oncogene ProteinsPyrazolesPyrimidinesReceptor Protein-Tyrosine KinasesSulfonamides

Identifiers

PMID26440741
PMCPMC4963009
OpenAlexW2179114654

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.