ArticleInternational journal of cardiology2016
HbA1c and all-cause mortality risk among patients with type 2 diabetes.
Article in International journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between ideal cardiovascular health metrics and risk of cardiovascular events or mortality: A meta-analysis of prospective studies.Clinical cardiology · 2017Pooled it
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- Association between glycated hemoglobin and risk of all-cause mortality in community patients with type 2 diabetes: A prospective cohort study.Journal of diabetes investigation · 2024Article
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- Association of obstructive sleep apnea symptoms with all-cause mortality and cause-specific mortality in adults with or without diabetes: A cohort study based on the NHANES.Journal of diabetes · 2024Article
- Glycemic control and atrial fibrillation: an intricate relationship, yet under investigation.Cardiovascular diabetology · 2022Review
- Body Mass Index Enhances the Associations Between Plasma Glucose and Mortality in Patients with Acute Coronary Syndrome.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
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- Prognostic significance of diabetes mellitus in patients with atrial fibrillation.Cardiovascular diabetology · 2021Article
- Predictions of diabetes complications and mortality using hba1c variability: a 10-year observational cohort study.Acta diabetologica · 2021Observational
- Time in Range in Relation to All-Cause and Cardiovascular Mortality in Patients With Type 2 Diabetes: A Prospective Cohort Study.Diabetes care · 2021Article
- Relationship between a single measurement at baseline of body mass index, glycated hemoglobin, and the risk of mortality and cardiovascular morbidity in type 2 diabetes mellitus.Cardiovascular endocrinology & metabolism · 2020Article
- Systemic risk factors contribute differently to the development of proliferative diabetic retinopathy and clinically significant macular oedema.Diabetologia · 2020Article
- Practical use of electronic health records among patients with diabetes in scientific research.Chinese medical journal · 2020Review
- Elevated HbA1c is not associated with recurrent venous thromboembolism in the elderly, but with all-cause mortality- the SWEETCO 65+ study.Scientific reports · 2020Article
- Relationship between hemoglobin A1c and serum troponin in patients with diabetes and cardiovascular events.Journal of diabetes and metabolic disorders · 2019Review
- Comparison of the Effects of Fasting Glucose, Hemoglobin ANutrients · 2019Observational
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Abstract
backgroundSeveral prospective studies have evaluated the association between glycosylated hemoglobin (HbA1c) and death risk among diabetic patients. However, the results have been inconsistent.
methodsWe performed a prospective study which included 13,334 men and 21,927 women with type 2 diabetes. Cox proportional hazards regression models were used to estimate the association of different levels of HbA1c with all-cause mortality.
resultsDuring a mean follow up of 8.7 years, 4199 (2082 men and 2117 women) patients died. The multivariable-adjusted hazard ratios (HRs) of all-cause mortality associated with different levels of HbA1c at baseline (<6.0%, 6.0-6.9% [reference], 7.0-7.9, 8.0-8.9%, 9.0-9.9%, 10.0-10.9%, and ≥11.0%) were 1.06, 1.00, 1.10, 0.93, 1.26, 1.18 and 1.31 (Pnon-linear=0.008) for men, and 1.21, 1.00, 1.01, 1.08, 1.30, 1.30 and 1.74 (Pnon-linear<0.001) for women, respectively. The J-shaped association of HbA1c with all-cause mortality was confirmed among African American and white diabetic patients, patients who were more than 50 years old, never smoked or used insulin. When we used an updated mean value of HbA1c, the J-shaped association of HbA1c with the risk of all-cause mortality did not change.
conclusionsOur study demonstrated a J-shaped association between HbA1c and the risk of all-cause mortality among men and women with type 2 diabetes. Both high and low levels of HbA1c were associated with an increased risk of all-cause mortality.
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