SynthesisOncotarget2015
Detection of cancer through exhaled breath: a systematic review.
Synthesis in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04022109 (Screening of Gastric Cancer Via Breath Volatile Organic Compounds by Hybrid Sensing Approach), which is not on this map. Cited by 72 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Screening of Gastric Cancer Via Breath Volatile Organic Compounds by Hybrid Sensing Approach
Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 181 citations in OpenAlex.
- Diagnostic Performance of Electronic Noses in Cancer Diagnoses Using Exhaled Breath: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- Breath based volatile organic compounds in the detection of breast, lung, and colorectal cancers: A systematic review.Cancer biomarkers : section A of Disease markers · 2017Pooled it
- Cross-platform mass spectrometry annotation in breathomics of oesophageal-gastric cancer.Scientific reports · 2018Trial
- High-performance gas measurement systems-bridging the gap between sensors and analytics.Analytical and bioanalytical chemistry · 2026Review
- Breath Aldehyde Profiling using PFBHA-GC/MS as a Prostate Cancer Biomarker.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Article
- Online monitoring and stable isotope tracing of cancer associated volatiles in murine model captures tumor associated markers in vivo.Analytica chimica acta · 2025Article
- Volatile Organic Compounds in Biological Matrices as a Sensitive Weapon in Cancer Diagnosis.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Chemical Nose-Based Non-Invasive Detection of Breast Cancer Using Exhaled Breath.Sensors (Basel, Switzerland) · 2025Article
- Metabolomics in cancer detection: A review of techniques, biomarkers, and clinical utility.BioMedicine · 2025Review
- Machine Learning Model Discriminate Ischemic Heart Disease Using Breathome Analysis.Biomedicines · 2024Article
- A cross-sectional study on metoprolol concentrations in various biological samples and their inter-correlations.BMC pharmacology & toxicology · 2024Article
- Partial role of volatile organic compounds in behavioural responses of mice to bedding from cancer-affected congeners.Biology open · 2024Article
- Porosity Engineering of Dried Smart Poly(Biomacromolecules · 2024Article
- Review
- Breathomics Detect the Cardiovascular Disease: Delusion or Dilution of the Metabolomic Signature.Current cardiology reviews · 2024Review
- Volatilome is Inflammasome- and Lipidome-dependent in Ischemic Heart Disease.Current cardiology reviews · 2024Review
- Advancing Colorectal Cancer Diagnosis with AI-Powered Breathomics: Navigating Challenges and Future Directions.Diagnostics (Basel, Switzerland) · 2023Review
- Article
- The Detection of Colorectal Cancer through Machine Learning-Based Breath Sensor Analysis.Diagnostics (Basel, Switzerland) · 2023Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTimely diagnosis of cancer represents a challenging task; in particular, there is a need for reliable non-invasive screening tools that could achieve high levels of adherence at virtually no risk in population-based screening. In this review, we summarize the current evidence of exhaled breath analysis for cancer detection using standard analysis techniques and electronic nose.
methodsRelevant studies were identified searching Pubmed and Web of Science databases until April 30, 2015. Information on breath test performance, such as sensitivity and specificity, was extracted together with volatile compounds that were used to discriminate cancer patients from controls. Performance of different breath analysis techniques is provided for various cancers together with information on methodological issues, such as breath sampling protocol and validation of the results.
resultsOverall, 73 studies were included, where two-thirds of the studies were conducted on lung cancer. Good discrimination usually required a combination of multiple biomarkers, and area under the receiver operating characteristic curve or accuracy reached levels of 0.9 or higher in multiple studies. In 25% of the reported studies, classification models were built and validated on the same datasets. Huge variability was seen in different aspects among the studies.
conclusionsAnalyses of exhaled breath yielded promising results, although standardization of breath collection, sample storage and data handling remain critical issues. In order to foster breath analysis implementation into practice, larger studies should be implemented in true screening settings, paying particular attention to standardization in breath collection, consideration of covariates, and validation in independent population samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.