Evidence map›Paper›PMID 26439987›Full record

ArticleOncotarget2015

MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular senescence.

Malathi Ramalinga, Arpita Roy, Anvesha Srivastava, Asmita Bhattarai, Varsha Harish, Simeng Suy, Sean Collins, Deepak Kumar

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 89 citations in OpenAlex.

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  12. Role of Non-Coding RNAs in Colorectal Cancer: Focus on Long Non-Coding RNAs.International journal of molecular sciences · 2022
    Review
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  18. Virus, Exosome, and MicroRNA: New Insights into Autophagy.Advances in experimental medicine and biology · 2022
    Article
  19. MicroRNA‑223‑induced inhibition of theMolecular medicine reports · 2021
    Article
  20. Berberine Ameliorates Hepatic Insulin Resistance by Regulating microRNA-146b/SIRT1 Pathway.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Malathi RamalingaCancer Research Laboratory, Division of Science and Mathematics, University of the District of Columbia, Washington, DC, USA.
Arpita RoyCancer Research Laboratory, Division of Science and Mathematics, University of the District of Columbia, Washington, DC, USA.
Anvesha SrivastavaCancer Research Laboratory, Division of Science and Mathematics, University of the District of Columbia, Washington, DC, USA.
Asmita BhattaraiCancer Research Laboratory, Division of Science and Mathematics, University of the District of Columbia, Washington, DC, USA.
Varsha HarishGroton School, Groton, MA, USA.
Simeng SuyLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Sean CollinsLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Deepak KumarCancer Research Laboratory, Division of Science and Mathematics, University of the District of Columbia, Washington, DC, USA.
University of the District of Columbia · USGeorgetown University Medical Center · US

Funding

MicroRNAs in African American Prostate CancerU01CA194730 · NCI · UNIVERSITY OF THE DISTRICT OF COLUMBIA · PI KUMAR, DEEPAK · 2015 to 2020
$1.8M
Functional Characterization of CCDC130 GeneSC1CA141935 · NCI · UNIVERSITY OF THE DISTRICT OF COLUMBIA · PI KUMAR, DEEPAK · 2009 to 2012
$1.4M
MICRORNAS in AFRICAN AMERICAN PROSTATE CANCERR21CA162264 · NCI · UNIVERSITY OF THE DISTRICT OF COLUMBIA · PI KUMAR, DEEPAK · 2011 to 2012
$420k
NCI NIH HHS CA141935NCI NIH HHS CA162264NCI NIH HHS CA194730NCI NIH HHS R21 CA162264NCI NIH HHS SC1 CA141935NCI NIH HHS U01 CA194730
6 · The paper itself

Abstract

Among a number of non-coding RNAs, role of microRNAs (miRNAs) in cancer cell proliferation, cancer initiation, development and metastasis have been extensively studied and miRNA based therapeutic approaches are being pursued. Prostate cancer (PCa) is a major health concern and several deregulated miRNAs have been described in PCa. miR-212 is differentially modulated in multiple cancers however its function remains elusive. In this study, we found that miR-212 is downregulated in PCa tissues when compared with benign adjacent regions (n = 40). Also, we observed reduced levels of circulatory miR-212 in serum from PCa patients (n = 40) when compared with healthy controls (n = 32). Elucidating the functional role of miR-212, we demonstrate that miR-212 negatively modulates starvation induced autophagy in PCa cells by targeting sirtuin 1 (SIRT1). Overexpression of miR-212 also leads to inhibition of angiogenesis and cellular senescence. In conclusion, our study indicates a functional role of miR-212 in PCa and suggests the development of miR-212 based therapies.

Indexed as

Area Under CurveAutophagyBiomarkers, TumorBlotting, WesternCell Line, TumorCellular SenescenceGene Expression Regulation, NeoplasticHumansLaser Capture MicrodissectionMaleMicroRNAsNeovascularization, PathologicProstatic NeoplasmsRNA, Small InterferingROC CurveSirtuin 1Biomarkers, TumorMicroRNAsMIRN212 microRNA, humanRNA, Small InterferingSIRT1 protein, humanSirtuin 1autophagymicroRNAmiR-212prostate cancerSIRT1

Identifiers

PMID26439987
PMCPMC4741465
OpenAlexW1870776631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.