ArticleProstate cancer and prostatic diseases2015
Preoperative low serum testosterone is associated with high-grade prostate cancer and an increased Gleason score upgrading.
Article in Prostate cancer and prostatic diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Low serum total testosterone level as a predictor of upgrading in low-risk prostate cancer patients after radical prostatectomy: A systematic review and meta-analysis.Investigative and clinical urology · 2022Pooled it
- PSA density correlates to pathology T stage and ISUP grade: insights from a cohort of 3568 radical prostatectomy cases.World journal of urology · 2025Article
- Risk factors for Gleason score upgrade from prostate biopsy to radical prostatectomy.Exploration of targeted anti-tumor therapy · 2024Review
- Article
- Hypogonadism and urologic surgeries: a narrative review.Translational andrology and urology · 2022Review
- The Relationship Between PSA and Total Testosterone Levels in Men With Prostate Cancer.The journal of sexual medicine · 2022Article
- CRMP4 CpG Hypermethylation Predicts Upgrading to Gleason Score ≥ 8 in Prostate Cancer.Frontiers in oncology · 2022Article
- Endogenous testosterone density as ratio of endogenous testosterone levels on prostate volume predicts tumor upgrading in low-risk prostate cancer.International urology and nephrology · 2021Article
- Analysis of risk factors for Gleason score upgrading after radical prostatectomy in a Chinese cohort.Cancer medicine · 2021Article
- Article
- Hypogonadism and prostate cancer detection on multiparametric MRI and mpMRI-TRUS fusion biopsy.International urology and nephrology · 2020Article
- Aggressiveness of Localized Prostate Cancer: the Key Value of Testosterone Deficiency Evaluated by Both Total and Bioavailable Testosterone: AndroCan Study Results.Hormones & cancer · 2019Article
- Association between age-related reductions in testosterone and risk of prostate cancer-An analysis of patients' data with prostatic diseases.International journal of cancer · 2017Article
- Article
- Gleason group concordance between biopsy and radical prostatectomy specimens: A cohort study from Prostate Cancer Outcome Registry - Victoria.Prostate international · 2016Article
- Prostate Health Index (Asian journal of andrologyObservational
- Serum testosterone as a biomarker for second prostatic biopsy in men with negative first biopsy for prostatic cancer and PSA>4ng/mL, or with PIN biopsy result.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Clinical and pathologic factors predicting reclassification in active surveillance cohorts.International braz j urol : official journal of the Brazilian Society of UrologyReview
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo compare histological feature of prostate cancer (PCa) according androgenic status in patients who underwent radical prostatectomy (RP).
methodsBetween March 2007 and September 2013, we prospectively analysed 937 patients who were referred to our centre for RP. Clinical, pathological and biological data have been prospectively collected. Preoperative total testosterone (TT) and bioavailable testosterone (BT) serum determinations were carried out. The threshold for low serum testosterone was set at TT<3 ng/ml. Preoperative PSA value was registered. Gleason score (GS) and predominant Gleason pattern were determined in prostate biopsies and in prostate tissue specimens, crosschecked by two uro-pathologists.
resultsNine hundred and thirty-seven consecutive patients were included. In all, 14.9% patients had low TT in the population. An exact match between biopsy and prostate specimens in GS grading was observed for 50.6% patients (n=474). Also, 40.9% of all patients were upgraded (n=383): 45.3% (n=63) in low serum testosterone patients and 40.1% (n=320) in normal serum testosterone patients. For prostate specimens, the proportion of patients with predominant Gleason pattern 4 was higher in patients with low TT compared with normal TT (41.7% vs 29.1%, P=0.0029). In all, 20.1% were upgraded from predominant Gleason pattern 3 on biopsies specimen to predominant Gleason 4 pattern on the prostate specimen in patients with low TT, whereas 11.6% were upgraded for normal TT patients (P=0.002).
conclusionsLow serum testosterone is an independent risk factor for predominant Gleason pattern 4 on prostate specimen after RP and for upgrading from low- to high-grade cancer between prostate needle biopsies and RP specimen. This observation should be taken into account in localised PCa management, especially for active surveillance or when a nerve-sparing approach is considered.
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