Trial reportEuropean journal of nutrition2017
Impact of preloading either dairy or soy milk on postprandial glycemia, insulinemia and gastric emptying in healthy adults.
Trial report in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07567443 (A Randomized Crossover Study Evaluating Postprandial Glucose and Insulin Responses to A1-Free and Conventional Milk With and Without a Delayed Lactose Challenge in Healthy Adults), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Crossover Study Evaluating Postprandial Glucose and Insulin Responses to A1-Free and Conventional Milk With and Without a Delayed Lactose Challenge in Healthy Adults
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Can the Substitution of Milk with Plant-Based Drinks Affect Health-Related Markers? A Systematic Review of Human Intervention Studies in Adults.Nutrients · 2023Pooled it
- The Association Between Coffee Consumption and Metabolic Syndrome in Adults: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Comparative efficacy of preloading plant-based versus animal-based proteins in evoking insulin and incretin responses to attenuate postprandial glucose.European journal of nutrition · 2025Trial
- Heated Corn Oil and 2,4-Decadienal Suppress Gastric Emptying and Energy Intake in Humans.Nutrients · 2021Trial
- Apple Preload Halved the Postprandial Glycaemic Response of Rice Meal on in Healthy Subjects.Nutrients · 2019Trial
- Co-Ingestion of Rice Bran Soymilk or Plain Soymilk with White Bread: Effects on the Glycemic and Insulinemic Response.Nutrients · 2018Trial
- Article
- Cooking Increased the Postprandial Glycaemic Response but Enhanced the Preload Effect of Air-Dried Jujube.Foods (Basel, Switzerland) · 2025Article
- Nutritional and sensory enhancement of traditional wheat-based yeasted steamed dumplings through oat flour fortification.Frontiers in nutrition · 2025Article
- A Specific Collagen Hydrolysate Improves Postprandial Glucose Tolerance in Normoglycemic and Prediabetic Mice and in a First Proof of Concept Study in Healthy, Normoglycemic and Prediabetic Humans.Food science & nutrition · 2024Article
- Article
- Apple preload increased postprandial insulin sensitivity of a high glycemic rice meal only at breakfast.European journal of nutrition · 2023Article
- Article
- The Effect of Soy and Whey Protein Supplementation on Glucose Homeostasis in Healthy Normal Weight Asian Indians.Journal of nutrition and metabolism · 2023Article
- Effects of low-GI biscuits as pre-loads or mid-meal snacks on post-prandial glycemic excursions in women with recent gestational diabetes: A protocol for a randomized crossover trial and an extended tailored intervention.Frontiers in nutrition · 2023Article
- Effects of soy protein isolate and soy peptide preload on gastric emptying rate and postprandial glycemic control in healthy humans.Journal of physiological anthropology · 2022Article
- Development of low glycemic index instant Phirni (pudding) mix-its visco-thermal, morphological and rheological characterization.Scientific reports · 2022Article
- Perspective: Soy-based Meat and Dairy Alternatives, Despite Classification as Ultra-processed Foods, Deliver High-quality Nutrition on Par with Unprocessed or Minimally Processed Animal-based Counterparts.Advances in nutrition (Bethesda, Md.) · 2022Article
- The Role of Bovine and Non-Bovine Milk in Cardiometabolic Health: Should We Raise the "Baa"?Nutrients · 2022Review
- Oat-Based Foods: Chemical Constituents, Glycemic Index, and the Effect of Processing.Foods (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMilk protein ingestion reduces post-meal glycemia when consumed either before or together with carbohydrate foods. The aim of this study was to compare the effects of dairy and soy milk consumed either before (preload) or together with (co-ingestion) a carbohydrate (bread), on postprandial blood glucose, insulin and gastric emptying in healthy participants.
methodsTwelve healthy Chinese male participants were studied on five separate occasions using a randomized crossover design. White wheat bread consumed with water was used as a reference meal. Capillary and venous bloods were sampled pretest and 3.5 h post-test meal for glucose and insulin measurement. Gastric emptying was measured using real-time ultrasonography.
resultsCo-ingestion of dairy milk or soy milk with bread lowered postprandial blood glucose response and glycemic index. Co-ingesting soy milk with bread increased insulin response and insulinemic index significantly compared to co-ingestion of dairy milk and preload treatments. Preloads (30 min prior to bread) significantly lowered postprandial glycemia and insulinemia compared to co-ingestion. Gastric emptying was slower after co-ingesting dairy milk with bread than after reference meal.
conclusionsPreloading either soy milk or dairy milk results in greater reduction in glycemic response compared to co-ingestion alone. This dietary practice may have therapeutic advantage in communities consuming high GI diets. Optimal glucose control may have the potential for increasing the time of transition from prediabetes to type 2 diabetes in Asian communities. CLINICAL
trial registrationThis trial was registered at clinicaltrials.gov as NCT 02151188.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.