ArticleBrain pathology (Zurich, Switzerland)2016
The Relationship Between Development of Neuronal and Astrocytic Tau Pathologies in Subcortical Nuclei and Progression of Argyrophilic Grain Disease.
Article in Brain pathology (Zurich, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Making tau amyloid models in vitro: a crucial and underestimated challenge.FEBS letters · 2025Review
- Pure argyrophilic grain disease revisited: independent effects on limbic, neocortical, and striato-pallido-nigral degeneration and the development of dementia in a series with a low to moderate Braak stage.Acta neuropathologica communications · 2024Article
- Age-Related Pathology in Corticobasal Degeneration.International journal of molecular sciences · 2024Article
- Amygdala granular fuzzy astrocytes as lesions preceding development of argyrophilic grains: data from 239 autopsy cases.Free neuropathology · 2022Article
- Risk of neurodegenerative disease due to tau phosphorylation changes and arsenic exposure via drinking water.Toxicology research · 2021Article
- Factors associated with development and distribution of granular/fuzzy astrocytes in neurodegenerative diseases.Brain pathology (Zurich, Switzerland) · 2020Article
- Astroglia and Tau: New Perspectives.Frontiers in aging neuroscience · 2020Review
- Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain.Acta neuropathologica communications · 2018Article
- Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers.Journal of Alzheimer's disease : JAD · 2018Review
- Protein astrogliopathies in human neurodegenerative diseases and aging.Brain pathology (Zurich, Switzerland) · 2017Review
- Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).Journal of neuropathology and experimental neurology · 2017Article
- Roles of tau protein in health and disease.Acta neuropathologica · 2017Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progressive supranuclear palsy (PSP) cases frequently have argyrophilic grain disease (AGD). However, the PSP-like tau pathology in AGD cases has not been fully clarified. To address this, we examined tau pathologies in the subcortical nuclei and frontal cortex in 19 AGD cases that did not meet the pathological criteria of PSP or corticobasal degeneration, nine PSP cases and 20 Braak NFT stage-matched controls. Of the 19 AGD cases, five (26.3%) had a few Gallyas-positive tau-positive tufted astrocytes (TAs) and Gallyas-negative tau-positive TA-like astrocytic inclusions (TAIs), and six (31.6%) had only TAIs in the striatum and/or frontal cortex. Subcortical tau pathology was sequentially and significantly greater in AGD cases lacking these tau-positive astrocytic lesions, AGD cases having them, and PSP cases than in controls. There was a significant correlation between three histologic factors, including the AGD stage and the quantities of subcortical neuronal and astrocytic tau pathologies. Tau immunoblotting demonstrated 68- and 64-kDa bands and 33-kDa low-molecular mass tau fragments in PSP cases, and although with lesser intensity, in AGD cases with and without TAs and TAIs also. Given these findings, the progression of AGD may be associated with development of the neuronal and astrocytic tau pathologies characteristic of PSP.
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