Evidence map›Paper›PMID 26439430›Full record

Trial reportDepression and anxiety2015

EXPLORING PERSONALITY DIAGNOSIS STABILITY FOLLOWING ACUTE PSYCHOTHERAPY FOR CHRONIC POSTTRAUMATIC STRESS DISORDER.

John C Markowitz, Eva Petkova, Tatyana Biyanova, Ke Ding, Eun Jung Suh, Yuval Neria

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Depression and anxiety, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00739765 nacompletednot on this map

Psychotherapies for Chronic Post-Traumatic Stress Disorder

TypeinterventionalSponsorNew York State Psychiatric InstituteRan2008 to 2014Enrolled110ConditionsPost-Traumatic Stress DisorderArmsInterpersonal Psychotherapy, Prolonged Exposure Therapy, Relaxation Therapy
NCT07664631 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Stimulant Medications in PTSD

TypeinterventionalSponsorUniversity of ChicagoRan2026 to 2027Enrolled40ConditionsAdderall, PTSD, Post Traumatic Stress DisorderArmsPlacebo, Adderall
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

John C MarkowitzNew York State Psychiatric Institute and Columbia University College of Physicians & Surgeons, New York, New York.
Eva PetkovaNew York State Psychiatric Institute and Columbia University College of Physicians & Surgeons, New York, New York.
Tatyana BiyanovaNew York State Psychiatric Institute and Columbia University College of Physicians & Surgeons, New York, New York.
Ke DingNew York State Psychiatric Institute and Columbia University College of Physicians & Surgeons, New York, New York.
Eun Jung SuhNew York State Psychiatric Institute and Columbia University College of Physicians & Surgeons, New York, New York.
Yuval NeriaNew York State Psychiatric Institute and Columbia University College of Physicians & Surgeons, New York, New York.
Columbia University · US

Funding

Psychotherapies for Chronic Posttraumatic Stress DisorderR01MH079078 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MARKOWITZ, JOHN C · 2008 to 2012
$3.1M
NIMH NIH HHS R01 MH079078
6 · The paper itself

Abstract

backgroundAxis I comorbidity complicates diagnosing axis II personality disorders (PDs). PDs might influence Axis I outcome. No research has examined psychotherapy effects on PDs of treating Axis I comorbidity. Secondary analysis of a randomized controlled trial examined PD diagnostic stability after brief psychotherapy of chronic posttraumatic stress disorder (PTSD).

methodsPatients with chronic PTSD were randomly assigned to 14 weeks of prolonged exposure, interpersonal psychotherapy, or relaxation therapy. Assessments included the Structured Clinical Interview for DSM-IV, Patient Version (SCID-P) and Structured Clinical Interview for DSM-IV Axis II Disorders (SCID-II) at baseline, week 14, and for treatment responders (≥30% clinician-administered PTSD scale improvement, defined a priori) at week 26 follow-up. We hypothesized patients whose PTSD improved would retain fewer baseline PD diagnoses posttreatment, particularly with personality traits PTSD mimics, e.g. paranoid and avoidant.

resultsForty-seven (47%) of 99 SCID-II patients evaluated at baseline received a SCID-II diagnosis: paranoid (28%), obsessive-compulsive (27%), and avoidant (23%) PDs were most prevalent. Among 78 patients who repeated SCID-II evaluations posttreatment, 45% (N = 35) had baseline PD diagnoses, of which 43% (N = 15/35) lost at week 14. Three (7%) patients without baseline PDs acquired diagnoses at week 14; 10 others shifted diagnoses. Treatment modality and PTSD response were unrelated to PD improvement. Of treatment responders reevaluated at follow-up (N = 44), 56% with any baseline Axis II diagnosis had none at week 26.

conclusionThis first evaluation of Axis I psychotherapy effects on personality disorder stability found that acutely treating a chronic state decreased apparent trait-across most PDs observed. These exploratory findings suggest personality diagnoses may have limited prognostic meaning in treating chronic PTSD.

Indexed as

AdolescentAdultAgedChronic DiseaseFemaleHumansMaleMiddle AgedPersonality DisordersPsychotherapyRelaxation TherapyStress Disorders, Post-TraumaticYoung Adultassessment/diagnosisCBTIPTpersonality disorderPTSD

Identifiers

PMID26439430
PMCPMC4674381
OpenAlexW2148769438

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.