Evidence map›Paper›PMID 26439406›Full record

ReviewNature reviews. Rheumatology2016

Strategies for the prevention of knee osteoarthritis.

Ewa M Roos, Nigel K Arden

4 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 283 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
283citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04956393 nacompletednot on this mapstarted 2021, after this paper: background citation

Proof-of-Concept of the SOAR (Stop OsteoARthritis) Program: A Randomized Delayed-Control Trial

TypeinterventionalSponsorUniversity of British ColumbiaRan2021 to 2023Enrolled58ConditionsArthritis, Osteoarthritis, Arthritis Knee, Osteo Arthritis KneeArmsImmediate 8-Week SOAR Program, Delayed 8-Week SOAR Program
NCT05096806 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Effects of Semi-standarized Acupuncture in Chronical Symptomatic Osteoarthritis of the Knee Through: A Randomized Controlled Trial

TypeinterventionalSponsorUniversitat de GironaRan2022 to 2024Enrolled56ConditionsOsteoarthritis, KneeArmsAcupuncture, TENS
NCT05975957 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Photobiomodulation Therapy to Reduce Pain and Inflammation in Patients With Gonarthrosis: a Multicenter Randomized, Double-blind, Placebo-controlled Clinical Trial

TypeinterventionalSponsorD'Or Institute for Research and EducationRan2023 to 2025Enrolled238ConditionsOsteoarthritis, GonarthrosisArmsPhotomodulation Therapy with the Light-Aid system, Control
NCT06065410 nacompletednot on this mapstarted 2022, after this paper: background citation

Research Assistant Doctor

TypeinterventionalSponsorGazi UniversityRan2022 to 2023Enrolled40ConditionsKnee OsteoarthritisArmsBaseline, Intrinsic focus, White noise, environmental sound
3 · Its place in the literature

Who cites it

283 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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223 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ewa M RoosResearch Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.
Nigel K ArdenBotnar Research Centre, Nuffield Orthopedic Centre, Oxford OX3 7LD, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) has been thought of as a disease of cartilage that can be effectively treated surgically at severe stages with joint arthroplasty. Today, OA is considered a whole-organ disease that is amenable to prevention and treatment at early stages. OA develops slowly over 10-15 years, interfering with activities of daily living and the ability to work. Many patients tolerate pain, and many health-care providers accept pain and disability as inevitable corollaries of OA and ageing. Too often, health-care providers passively await final 'joint death', necessitating knee and hip replacements. Instead, OA should be viewed as a chronic condition, where prevention and early comprehensive-care models are the accepted norm, as is the case with other chronic diseases. Joint injury, obesity and impaired muscle function are modifiable risk factors amenable to primary and secondary prevention strategies. The strategies that are most appropriate for each patient should be identified, by selecting interventions to correct--or at least attenuate--OA risk factors. We must also choose the interventions that are most likely to be acceptable to patients, to maximize adherence to--and persistence with--the regimes. Now is the time to begin the era of personalized prevention for knee OA.

Indexed as

AgingExercise TherapyPatient Education as TopicPhysical Therapy ModalitiesWeight LossAge DistributionBody Mass IndexDenmarkEvidence-Based MedicineHumansObesityOsteoarthritis, KneePrecision MedicineRisk FactorsSex DistributionTreatment Outcome

Identifiers

PMID26439406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.