Evidence map›Paper›PMID 26439298›Full record

ReviewTrends in microbiology2015

Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network.

Christopher M Goodwin, Shihao Xu, Joshua Munger

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. The return of metabolism: biochemistry and physiology of glycolysis.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Perturbation ofJournal of virology · 2025
    Article

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christopher M GoodwinDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA.
Shihao XuDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA.
Joshua MungerDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA. Electronic address: josh.munger@rochester.edu.

Funding

Training Program in Oral ScienceT90DE021985 · NIDCR · UNIVERSITY OF ROCHESTER · PI OVITT, CATHERINE, YULE, DAVID I · 2011 to 2021
$5.6M
Metabolic regulatory mechanisms essential for Human Cytomegalovirus replicationR01AI081773 · NIAID · UNIVERSITY OF ROCHESTER · PI MUNGER, JOSHUA C · 2010 to 2014
$1.7M
Metabolic regulatory mechanisms essential for Human Cytomegalovirus replicationR56AI081773 · NIAID · UNIVERSITY OF ROCHESTER · PI MUNGER, JOSHUA C · 2015 to 2015
$384k
NIAID NIH HHS R01 AI081773NIAID NIH HHS R56 AI081773NIDCR NIH HHS T90 DE021985
6 · The paper itself

Abstract

Host cells possess the metabolic assets required for viral infection. Recent studies indicate that control of the host's metabolic resources is a core host-pathogen interaction. Viruses have evolved mechanisms to usurp the host's metabolic resources, funneling them towards the production of virion components as well as the organization of specialized compartments for replication, maturation, and dissemination. Consequently, hosts have developed a variety of metabolic countermeasures to sense and resist these viral changes. The complex interplay between virus and host over metabolic control has only just begun to be deconvoluted. However, it is clear that virally induced metabolic reprogramming can substantially impact infectious outcomes, highlighting the promise of targeting these processes for antiviral therapeutic development.

Indexed as

Host-Pathogen InteractionsMetabolic Networks and PathwaysMetabolismCarcinogenesisCitric Acid CycleGlycolysisHumansProtein BiosynthesisViral TropismVirionVirusesVirus Physiological PhenomenaVirus Replicationcitric acid cycleenergyfatty acidglycolysisimmunityinfectionlipidmetabolismvirus

Identifiers

PMID26439298
PMCPMC4679435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.