ArticleScientific reports2015
Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
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Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis.Frontiers in aging neuroscience · 2023Pooled it
- A multilayer multimodal detection and prediction model based on explainable artificial intelligence for Alzheimer's disease.Scientific reports · 2021Trial
- Alterations in topological and dynamical parameters correlate with disease biomarkers and neuropsychological scores in prodromic stages of dementia.Scientific reports · 2026Article
- Blind Identification of Altered Functional Subnetworks in Alzheimer's Disease Using Resting-State fMRI.Biomedical engineering and computational biology · 2026Article
- Stable individualized brain computing model informed by spatiotemporal co-activity patterns.PLoS computational biology · 2025Article
- Review
- An interpretable generative multimodal neuroimaging-genomics framework for decoding Alzheimer's disease.Journal of neural engineering · 2025Article
- Smoking alters effective connectivity of resting-state brain networks in mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Article
- Co-Community Network Analysis Reveals Alterations in Brain Networks in Alzheimer's Disease.Brain sciences · 2025Article
- Specificity of functional network connectivity during the AD prodromal phase in mild cognitive impairment.Frontiers in psychiatry · 2025Article
- The alterations in brain network functional gradients and dynamic functional connectivity in Alzheimer's disease: a resting-state fMRI study.Frontiers in aging neuroscience · 2025Article
- Alterations of the default mode network, salience network, and frontoparietal network in non-problematic Internet use and their association with mood regulation: from an internet literacy perspective.Frontiers in neuroscience · 2025Article
- Article
- Novel Alzheimer's disease subtypes based on functional brain connectivity in human connectome project.Scientific reports · 2024Article
- Disrupted morphological brain network organization in subjective cognitive decline and mild cognitive impairment.Brain imaging and behavior · 2024Article
- Associations between Education Years and Resting-state Functional Connectivity Modulated byClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Analysis of Resting-State Functional Magnetic Resonance Imaging in Alzheimer's Disease.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Transcranial direct current stimulation and neuronal functional connectivity in MCI: role of individual factors associated to AD.Frontiers in psychiatry · 2024Article
- Detection of neurophysiological markers of cognitive reserve: an EEG study.Frontiers in aging neuroscience · 2024Article
- Functional network centrality indicates interactions between APOE4 and age across the clinical spectrum of Alzheimer's Disease.NeuroImage. Clinical · 2024Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) patients and those with high-risk mild cognitive impairment are increasingly considered to have dysfunction syndromes. Large-scale network studies based on neuroimaging techniques may provide additional insight into AD pathophysiology. The aim of the present study is to evaluate the impaired network functional connectivity with the disease progression. For this purpose, we explored altered functional connectivities based on previously well-defined brain areas that comprise the five key functional systems [the default mode network (DMN), dorsal attention network (DAN), control network (CON), salience network (SAL), sensorimotor network (SMN)] in 35 with AD and 27 with mild cognitive impairment (MCI) subjects, compared with 27 normal cognitive subjects. Based on three levels of analysis, we found that intra- and inter-network connectivity were impaired in AD. Importantly, the interaction between the sensorimotor and attention functions was first attacked at the MCI stage and then extended to the key functional systems in the AD individuals. Lower cognitive ability (lower MMSE scores) was significantly associated with greater reductions in intra- and inter-network connectivity across all patient groups. These profiles indicate that aberrant intra- and inter-network dysfunctions might be potential biomarkers or predictors of AD progression and provide new insight into AD pathophysiology.
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