ArticlePloS one2015
Seventy Years of Asthma in Italy: Age, Period and Cohort Effects on Incidence and Remission of Self-Reported Asthma from 1940 to 2010.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Inflammatory Bowel Disease in Patients With Atopic Dermatitis and Allergic Rhinitis: A Nationwide Case-Control Study.International journal of rheumatic diseases · 2026Article
- Asthma incidence can be influenced by climate change in Italy: findings from the GEIRD study-a climatological and epidemiological assessment.Scientific reports · 2023Article
- Asthma, COPD, Respiratory, and Allergic Health Effects in an Adult Population Living near an Italian Refinery: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2023Article
- Asthma remission: what is it and how can it be achieved?The European respiratory journal · 2022Review
- Clinical Remission of Asthma and Allergic Rhinitis - in a Longitudinal Population Study.Journal of asthma and allergy · 2022Article
- Longitudinal Asthma Patterns in Italian Adult General Population Samples: Host and Environmental Risk Factors.Journal of clinical medicine · 2020Article
- Asthma: A Loss of Post-natal Homeostatic Control of Airways Smooth Muscle With Regression Toward a Pre-natal State.Frontiers in pediatrics · 2020Review
- Time and age trends in smoking cessation in Europe.PloS one · 2019Article
- Article
- BMI at school age and incident asthma admissions in early adulthood: a prospective study of 310,211 children.Clinical epidemiology · 2018Article
- Sex-specific association between asthma and hypertension in nationally representative young Korean adults.Scientific reports · 2017Article
- A population-based cohort of adults with asthma: mortality and participation in a long-term follow-up.European clinical respiratory journal · 2017Article
- Changes in symptoms of asthma and rhinitis by sensitization status over ten years in a cohort of young Chilean adults.BMC pulmonary medicine · 2016Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is well known that asthma prevalence has been increasing all over the world in the last decades. However, few data are available on temporal trends of incidence and remission of asthma.
objectiveTo evaluate the rates of asthma incidence and remission in Italy from 1940 to 2010.
methodsThe subjects were randomly sampled from the general Italian population between 1991 and 2010 in the three population-based multicentre studies: ECRHS, ISAYA, and GEIRD. Individual information on the history of asthma (age at onset, age at the last attack, use of drugs for asthma control, co-presence of hay-fever) was collected on 35,495 subjects aged 20-84 and born between 1925-1989. Temporal changes in rates of asthma incidence and remission in relation to age, birth cohort and calendar period (APC) were modelled using Poisson regression and APC models.
resultsThe average yearly rate of asthma incidence was 2.6/1000 (3,297 new cases among 1,263,885 person-years). The incidence rates have been linearly increasing, with a percentage increase of +3.9% (95%CI: 3.1-4.5), from 1940 up to the year 1995, when the rates begun to level off. The stabilization of asthma incidence was mainly due to a decrease in the rates of atopic asthma after 1995, while non-atopic asthma has continued to increase. The overall rate of remission was 43.2/1000person-years, and it did not vary significantly across generations, but was associated with atopy, age at asthma onset and duration of the disease.
conclusionsAfter 50 years of a continuous upward trend, the rates of asthma incidence underwent a substantial stabilization in the late 90s. Despite remarkable improvements in the treatment of asthma, the rate of remission did not change significantly in the last seventy years. Some caveats are required in interpreting our results, given that our estimates are based on self-reported events that could be affected by the recall bias.
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