ArticleProceedings of the National Academy of Sciences of the United States of America2015
Optofluidic wavelength division multiplexing for single-virus detection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Wearable and Thermal Drift-Compensated Monitoring System Based on Fiber Bragg Grating Sensors for a 3D-Printed Foot Prosthesis.Sensors (Basel, Switzerland) · 2025Article
- Ultrasensitive detection of intact SARS-CoV-2 particles in complex biofluids using microfluidic affinity capture.Science advances · 2025Article
- Adaptive time modulation technique for multiplexed on-chip particle detection across scales.Optica · 2023Article
- Beyond Karl Fischer titration: a monolithic quantum cascade sensor for monitoring residual water concentration in solvents.Lab on a chip · 2023Article
- Machine learning at the edge for AI-enabled multiplexed pathogen detection.Scientific reports · 2023Article
- Nanowire-based integrated photonics for quantum information and quantum sensing.Nanophotonics (Berlin, Germany) · 2023Review
- Fluorescent Biosensors for the Detection of Viruses Using Graphene and Two-Dimensional Carbon Nanomaterials.Biosensors · 2022Review
- A Critical Review on the Sensing, Control, and Manipulation of Single Molecules on Optofluidic Devices.Micromachines · 2022Review
- Fast custom wavelet analysis technique for single molecule detection and identification.Nature communications · 2022Article
- FPGA Integrated Optofluidic Biosensor for Real-Time Single Biomarker Analysis.IEEE photonics journal · 2022Article
- A merged lattice metal nanohole array based dual-mode plasmonic laser with an ultra-low threshold.Nanoscale advances · 2022Article
- Exploration of nanozymes in viral diagnosis and therapy.Exploration (Beijing, China) · 2022Review
- Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures.Biomedicines · 2022Review
- Recent advances in integrated solid-state nanopore sensors.Lab on a chip · 2021Review
- Free-Space Excitation of Optofluidic Devices for Pattern-Based Single Particle Detection.IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society · 2021Article
- Ultrasensitive detection of SARS-CoV-2 RNA and antigen using single-molecule optofluidic chip.APL photonics · 2021Article
- Optofluidic multiplex detection of single SARS-CoV-2 and influenza A antigens using a novel bright fluorescent probe assay.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- On-Chip Optical Detection of Viruses: A Review.Advanced photonics research · 2021Article
- Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaks.Proceedings. Mathematical, physical, and engineering sciences · 2020Review
- 7X multiplexed, optofluidic detection of nucleic acids for antibiotic-resistance bacterial screening.Optics express · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Optical waveguides simultaneously transport light at different colors, forming the basis of fiber-optic telecommunication networks that shuttle data in dozens of spectrally separated channels. Here, we reimagine this wavelength division multiplexing (WDM) paradigm in a novel context--the differentiated detection and identification of single influenza viruses on a chip. We use a single multimode interference (MMI) waveguide to create wavelength-dependent spot patterns across the entire visible spectrum and enable multiplexed single biomolecule detection on an optofluidic chip. Each target is identified by its time-dependent fluorescence signal without the need for spectral demultiplexing upon detection. We demonstrate detection of individual fluorescently labeled virus particles of three influenza A subtypes in two implementations: labeling of each virus using three different colors and two-color combinatorial labeling. By extending combinatorial multiplexing to three or more colors, MMI-based WDM provides the multiplexing power required for differentiated clinical tests and the growing field of personalized medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.