ArticleInfection and immunity2015
Pancreatic amylase is an environmental signal for regulation of biofilm formation and host interaction in Campylobacter jejuni.
Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Campylobacter jejuni strains isolated in Brazil have important virulence related genes and survive to different stress conditions.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Small worms big discoveries:Frontiers in cellular and infection microbiology · 2025Review
- Pathogenicity and virulence ofVirulence · 2024Review
- Evaluation of physical and chemical isolation methods to extract and purifyFrontiers in microbiology · 2024Article
- Evolution and Role of Proteases inBiomolecules · 2023Review
- Comparison of the Pathogenic Potential ofPathogens (Basel, Switzerland) · 2020Article
- Stimulation of biofilm formation by oxidative stress in Campylobacter jejuni under aerobic conditions.Virulence · 2016Article
- Campylobacter jejuni CsrA Regulates Metabolic and Virulence Associated Proteins and Is Necessary for Mouse Colonization.PloS one · 2016Article
- Glucose Metabolism via the Entner-Doudoroff Pathway inFrontiers in microbiology · 2016Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 1 country.
Funding
Abstract
Campylobacter jejuni is a commensal bacterium in the intestines of animals and birds and a major cause of food-borne gastroenteritis in humans worldwide. Here we show that exposure to pancreatic amylase leads to secretion of an α-dextran by C. jejuni and that a secreted protease, Cj0511, is required. Exposure of C. jejuni to pancreatic amylase promotes biofilm formation in vitro, increases interaction with human epithelial cell lines, increases virulence in the Galleria mellonella infection model, and promotes colonization of the chicken ileum. We also show that exposure to pancreatic amylase protects C. jejuni from stress conditions in vitro, suggesting that the induced α-dextran may be important during transmission between hosts. This is the first evidence that pancreatic amylase functions as an interkingdom signal in an enteric microorganism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.