Evidence map›Paper›PMID 26438720›Full record

ArticleJournal of diabetes science and technology2015

Incorporating an Exercise Detection, Grading, and Hormone Dosing Algorithm Into the Artificial Pancreas Using Accelerometry and Heart Rate.

Peter G Jacobs, Navid Resalat, Joseph El Youssef, Ravi Reddy, Deborah Branigan, Nicholas Preiser, John Condon, Jessica Castle

2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in Journal of diabetes science and technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02688218 nacompletednot on this mapstarted 2016, after this paper: background citation

Testing and Tuning a Multiparameter Exercise Detection Algorithm

TypeinterventionalSponsorOregon Health and Science UniversityRan2016 to 2018Enrolled30ConditionsType 1 DiabetesArmsAerobic Exercise, Resistance Exercise
NCT03090451 nacompletednot on this mapstarted 2017, after this paper: background citation

Evaluating the Dynamics of Insulin and Non-insulin Mediated Effects on Glucose During Aerobic Exercise in Subjects With Type 1 Diabetes

TypeinterventionalSponsorOregon Health and Science UniversityRan2017 to 2019Enrolled26ConditionsType 1 Diabetes Mellitus, HypoglycemiaArmsAerobic Exercise
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.

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  12. Metabolic Models, in Silico Trials, and Algorithms.Diabetes technology & therapeutics · 2025
    Review
  13. Metabolic Models, in Silico Trials, and Algorithms.Journal of diabetes science and technology · 2025
    Review
  14. Review
  15. Dosing Algorithms for Insulin Pumps.Diabetes spectrum : a publication of the American Diabetes Association · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Peter G JacobsDepartment of Biomedical Engineering, Oregon Health and Science University, Portland OR, USA jacobsp@ohsu.edu.
Navid ResalatDepartment of Biomedical Engineering, Oregon Health and Science University, Portland OR, USA.
Joseph El YoussefHarold Schnitzer Diabetes Health Center, Oregon Health and Science University, Portland OR, USA.
Ravi ReddyDepartment of Biomedical Engineering, Oregon Health and Science University, Portland OR, USA.
Deborah BraniganHarold Schnitzer Diabetes Health Center, Oregon Health and Science University, Portland OR, USA.
Nicholas PreiserDepartment of Biomedical Engineering, Oregon Health and Science University, Portland OR, USA.
John CondonDepartment of Biomedical Engineering, Oregon Health and Science University, Portland OR, USA.
Jessica CastleHarold Schnitzer Diabetes Health Center, Oregon Health and Science University, Portland OR, USA.
Oregon Health & Science University · US

Funding

OREGON CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024140 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2011
$61.1M
Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Mitigating risk in a closed loop system by exercise detection and miniaturizationDP3DK101044 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI CASTLE, JESSICA R, JACOBS, PETER G · 2013 to 2013
$2.9M
Optimization of an Adaptive Dual-Hormone External Endocrine Pancreas.K23DK090133 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI EL YOUSSEF, JOSEPH · 2011 to 2015
$863k
NCATS NIH HHS UL1 TR000128NCATS NIH HHS UL1TR000128NCRR NIH HHS UL1 RR024140NIDDK NIH HHS 1DP3DK101044NIDDK NIH HHS DP3 DK101044NIDDK NIH HHS K23 DK090133
6 · The paper itself

Abstract

In this article, we present several important contributions necessary for enabling an artificial endocrine pancreas (AP) system to better respond to exercise events. First, we show how exercise can be automatically detected using body-worn accelerometer and heart rate sensors. During a 22 hour overnight inpatient study, 13 subjects with type 1 diabetes wearing a Zephyr accelerometer and heart rate monitor underwent 45 minutes of mild aerobic treadmill exercise while controlling their glucose levels using sensor-augmented pump therapy. We used the accelerometer and heart rate as inputs into a validated regression model. Using this model, we were able to detect the exercise event with a sensitivity of 97.2% and a specificity of 99.5%. Second, from this same study, we show how patients' glucose declined during the exercise event and we present results from in silico modeling that demonstrate how including an exercise model in the glucoregulatory model improves the estimation of the drop in glucose during exercise. Last, we present an exercise dosing adjustment algorithm and describe parameter tuning and performance using an in silico glucoregulatory model during an exercise event.

Indexed as

AlgorithmsDrug Dosage CalculationsExerciseExercise TestHeart RatePancreas, ArtificialActigraphyBiomarkersBlood GlucoseComputer SimulationDiabetes Mellitus, Type 1Energy MetabolismEquipment DesignGlucagonHumansHypoglycemic AgentsBiomarkersBlood GlucoseGlucagonHypoglycemic AgentsInsulinaccelerometerenergy expenditureexerciseglucoregulatory modelheart ratehypoglycemia

Identifiers

PMID26438720
PMCPMC4667295
OpenAlexW2237750930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.