Evidence map›Paper›PMID 26438666›Full record

SynthesisOccupational and environmental medicine2015

The prevalence of hepatitis C among healthcare workers: a systematic review and meta-analysis.

Claudia Westermann, Claudia Peters, Birgitte Lisiak, Monica Lamberti, Albert Nienhaus

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Occupational and environmental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Review
  8. Mortality Risks of U.S. Healthcare Workers.American journal of preventive medicine · 2025
    Article
  9. Observational
  10. Bloodborne Infections Relevant to Dental Practice.International dental journal · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Management of hepatitis B and C in special population.World journal of gastroenterology · 2021
    Review
  15. Occupational Infections among Dental Health Workers in Germany-14-Year Time Trends.International journal of environmental research and public health · 2021
    Article
  16. Hepatitis C in healthcare personnel: follow-up analysis of treatments with direct-acting antiviral agents.Journal of occupational medicine and toxicology (London, England) · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Claudia WestermannUniversity Medical Center Hamburg-Eppendorf, Institute for Health Services Research in Dermatology and Nursing, Hamburg, Germany.
Claudia PetersUniversity Medical Center Hamburg-Eppendorf, Institute for Health Services Research in Dermatology and Nursing, Hamburg, Germany.
Birgitte LisiakInstitution for Statutory Accident Insurance and Prevention in Health and Welfare Services, Hamburg, Germany.
Monica LambertiDepartment of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
Albert NienhausUniversity Medical Center Hamburg-Eppendorf, Institute for Health Services Research in Dermatology and Nursing, Hamburg, Germany Institution for Statutory Accident Insurance and Prevention in Health and Welfare Services, Hamburg, Germany.
National Association of Statutory Health Insurance Physicians · DEUniversität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to estimate the prevalence of viral hepatitis C (HCV) infection among healthcare workers (HCWs) compared to the general population. A systematic search for the years 1989-2014 was conducted in the Medline, Embase and Cochrane databases. Studies on hepatitis C in HCWs were included if they incorporated either a control group or reference data for the general population. The study quality was classified as high, moderate or low. Pooled effect estimates were calculated to determine the odds of occupational infection. Heterogeneity between studies was analysed using the χ(2) test (p<0.10) and quantified using the I(2) test. 57 studies met our criteria for inclusion and 44 were included in the meta-analysis. Analysis of high and moderate quality studies showed a significantly increased OR for HCV infection in HCWs relative to control populations, with a value of 1.6 (95% CI 1.03 to 2.42). Stratification by study region gave an OR of 2.1 in low prevalence countries; while stratification by occupational groups gave an increased prevalence for medical (OR 2.2) and for laboratory staff (OR 2.2). The OR for professionals at high risk of blood contact was 2.7. The pooled analysis indicates that the prevalence of infection is significantly higher in HCWs than in the general population. The highest prevalence was observed among medical and laboratory staff. Prospective studies that focus on HCW-specific activity and personal risk factors for HCV infection are needed.

Indexed as

Health PersonnelHepatitis CHumansOccupational DiseasesPrevalenceRisk Factorsexposures and occupational groupsHealthcare workers < Materials

Identifiers

PMID26438666
PMCPMC4680146
OpenAlexW2248766705

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.